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2008 Fiscal Year Final Research Report

Analyzes of transcription and growth factors on secondary chondrogenesis such as mandibular condylar cartilage

Research Project

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Project/Area Number 17591901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHealth Sciences University of Hokkaido (2006-2008)
Tokyo Medical and Dental University (2005)

Principal Investigator

SHIBATA Shunichi  Health Sciences University of Hokkaido, 歯学部, 教授 (80187400)

Co-Investigator(Renkei-kenkyūsha) 山下 靖雄  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70014157)
須田 直人  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (90302885)
寺田 典夫  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (30251531)
Project Period (FY) 2005 – 2008
Keywords軟骨 / 二次軟骨 / 下顎頭 / 転写因子 / 成長因子
Research Abstract

4年間の研究期間で、下顎頭軟骨形成過程における転写因子(Runx2, Osterix, Sox9)、成長因子(IGF)の発現パターンが明らかになるとともに、新規軟骨細胞増殖因子であるcartducinの下顎頭軟骨形成に対する機能の一端が明らかとなった。この間に原著論文13報(いずれも査読ありの雑誌)を出版した。

  • Research Products

    (17 results)

All 2008 2007 2006 2005

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (4 results)

  • [Journal Article] An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis2008

    • Author(s)
      Shibata S. Yokohama-Tamaki T
    • Journal Title

      Journal of Anatomy 213

      Pages: 274-283

    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor I regulates apoptosis in condylar2008

    • Author(s)
      Yokota T. Shimokawa H. Shibata S. 他5名
    • Journal Title

      Journal of Dental Research 87

      Pages: 159-163

    • Peer Reviewed
  • [Journal Article] An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice2008

    • Author(s)
      Shibata S. Baba O. Oda T. 他5名
    • Journal Title

      Archives of Oral Biology 53

      Pages: 220-230

    • Peer Reviewed
  • [Journal Article] Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human2007

    • Author(s)
      Hiraoka S. Furuichi T. Nishimura G., Shibata S. 他14名
    • Journal Title

      Nature Medicine 13(11)

      Pages: 1363-7

    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice2007

    • Author(s)
      Fukuoka H. Shibata S. 他3名
    • Journal Title

      Journal of Anatomy 211

      Pages: 8-15

    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of syndecan-1 in the dental follicle of postnatal mouse teeth2007

    • Author(s)
      Shibata S. Dias RA 他3名
    • Journal Title

      Journal of Periodontology 78

      Pages: 1322-1328

    • Peer Reviewed
  • [Journal Article] Laser burn wound healing in naso-labial region of fetal and neonatal mice2007

    • Author(s)
      Nakasone A. Shibata S. 他3名
    • Journal Title

      Oral Diseases 13

      Pages: 45-50

    • Peer Reviewed
  • [Journal Article] Migration and particle clearance from hard-setting Ca(OH)2 and self-etching adhesive resin following direct pulp capping. J2007

    • Author(s)
      Kitasako Y. Shibata S. Tagami
    • Journal Title

      American Journal of Dentistry 19

      Pages: 370-375

    • Peer Reviewed
  • [Journal Article] Formation of acellular cementum-like layers with and without extrinsic fiber insertion along inert bone surfaces of aging c-Src gene knockout mice2006

    • Author(s)
      Baba O Miyata A Abe T Shibata S他5名
    • Journal Title

      European Journal of Oral Sciences 114

      Pages: 524-534

    • Peer Reviewed
  • [Journal Article] Structural features of incremental line-like striations in mandibular condylar cartilage of c-src-deficient mice2006

    • Author(s)
      Shibata S. Oda T. Abe T. 他2名
    • Journal Title

      Archives of Oral Biology 51

      Pages: 951-959

    • Peer Reviewed
  • [Journal Article] An in situ hybridization and histochemical study of developing and postnatal changes of mouse mandibular angular cartilage compared with condylar cartilage2006

    • Author(s)
      Shibata. S. Fujimori T. Yamashita Y
    • Journal Title

      cartilageJournal of Medical and Dental Sciences 53

      Pages: 41-50

    • Peer Reviewed
  • [Journal Article] An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible2006

    • Author(s)
      Shibata. S. Suda N. 他3名
    • Journal Title

      Journal of Anatomy 208

      Pages: 169-177

    • Peer Reviewed
  • [Journal Article] Syndecan-1 Expression during the Formation of Junctional Epithelium2005

    • Author(s)
      Dias R.A. Shibata S. 他4名
    • Journal Title

      Journal of Periodontology 76

      Pages: 696-704

    • Peer Reviewed
  • [Presentation] マウス下顎頭軟骨発生過程における IGF familyの発現に関する研究2008

    • Author(s)
      柴田俊一、 田巻玉器、鈴木裕子
    • Organizer
      第50回歯科基礎医学会総会
    • Place of Presentation
      有明コンベンションセンター
    • Year and Date
      2008-09-25
  • [Presentation] マウス下顎頭軟骨発生過程におけるcartducinの発現と機能解析2008

    • Author(s)
      田巻玉器、前田隆史、柴田俊一
    • Organizer
      第50回歯科基礎医学会総会
    • Place of Presentation
      有明コンベンションセンター
    • Year and Date
      2008-09-24
  • [Presentation] Expression of IGF Family in Developing Mouse Mandibular Condylar Cartilage2008

    • Author(s)
      Shibata S et al
    • Organizer
      86th General Session and Exhibition of the IADR
    • Place of Presentation
      Toronto convention center
    • Year and Date
      2008-07-02
  • [Presentation] 長期飼育c-src遺伝子欠損マウス下顎頭における肥大軟骨細胞の運命2007

    • Author(s)
      柴田俊一、馬場麻人 他3名
    • Organizer
      第49回歯科基礎医学会総会
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-08-30

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Published: 2010-06-10   Modified: 2016-04-21  

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