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2007 Fiscal Year Final Research Report Summary

Study on compensatory change of masticator muscle using masseter muscle suppression

Research Project

Project/Area Number 17592015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionTohoku University

Principal Investigator

FURUUCHI Toshi  Tohoku University, Tohoku University, Graduate School of Dentistry, Assistant Professor (50209160)

Co-Investigator(Kenkyū-buntansha) WATANABE Makoto  Graduate School of Dentistry, 大学院・歯学研究科, Professor (80091768)
SASANO Takashi  Graduate School of Dentistry, 大学院・歯学研究科, Professor (10125560)
TSUBOI Akito  Hospital, 病院, Associate Professor (00241646)
Project Period (FY) 2005 – 2007
Keywordsmastication / masticator muscle / masseter muscle / compensatory change
Research Abstract

1. Purpose Mastication needs cooperation of masticatory muscles, but the exact role of the each muscle for mastication is not completely clear. The purpose of this study was to evaluate the change of masticatory muscles under the unilateral masseter muscle dysfunction induced by Botulinum toxin A (BTXA) injection in rabbits. BTXA binds to presynaptic nerve endings and inhibits the release of acetylcholine, leading to temporary partial denervation and reduction of muscle fiber.
2. Materials and Methods White Japanese rabbits were injected with 10 units of BTXA into the left masseter muscle. The effect of a neuromuscular blockade of masseteric activity was evaluated with serial computer tomography (CT) scans with 0.63mm slice thickness and 0.1mm slice interval taken after 4 weeks.
3. Results The masseter muscle size of BTXA injected was reduced to about 80% against the control side. This indicated the morphologic change caused by the neuromuscular blockade.
4. Coclusion To study the exact role of each muscles for mastication, masseter mucle dysfunction was made by BTXA injection into the masseter muscle. The most suitable dose, timing and the degree of dysfunction were established. The elrctro-myography is considered to investigate the functional change. This animal model helps the understanding of the mechanism of tempolo-mandibular dysfunction.

  • Research Products

    (6 results)

All 2008 2007 2006

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (2 results)

  • [Journal Article] A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery2008

    • Author(s)
      Iikubo M, et. al.
    • Journal Title

      The British Journal of Radiology 81

      Pages: e84-e87

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery2008

    • Author(s)
      Mashiro Iikubo, et. al.
    • Journal Title

      The British Journal of Radiology 81

      Pages: 84-87

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurgery2007

    • Author(s)
      Iikubo M, et. al.
    • Organizer
      16 th International Congress of DentoMaxilloFacial Radiology
    • Place of Presentation
      Beijin
    • Year and Date
      2007-06-27
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A case of masticatory disturbance incidental to trigeminal schwannoma: changes in occlusal force and masticatory sensation before and after radiosurger2007

    • Author(s)
      Iikubo M, ed. al.
    • Organizer
      16th International Congress of DentoMaxilloFacial Radiology
    • Place of Presentation
      Beijin
    • Year and Date
      2007-06-27
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] BIRTH DEFECTS: NEW RESEARCH Chapter VII Maxillofacial Manifestations of Cleidocranial Dysplasia, Concentrating on Masseter Muscle Change.2006

    • Author(s)
      Toshi FURUUCHI , et. al.
    • Total Pages
      15(249)
    • Publisher
      Nova Science Publishers, Inc.
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] BIRTH DEFECTS: NEW RESEARCH Chapter VII Maxillofacial Manifestations of Cleidocranial Dysplasia, Concentrating on Masseter Muscle Change2006

    • Author(s)
      Toshi FURUUCHI ed. al.
    • Total Pages
      15
    • Publisher
      Nova Science Publishers, Inc.
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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