2007 Fiscal Year Final Research Report Summary
The role of COX-2, 3 expression in central sensitization on oral cancer pain
| Project/Area Number |
17592107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokai University |
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Principal Investigator |
AOKI Takuyuki Tokai University, School of Medicine, Lecturer (80297209)
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| Co-Investigator(Kenkyū-buntansha) |
KARAKIDA Kazunari Tokai University, School of Medicine, Lecturer (40246137)
TSUKINOKI Keiichi Kanagawa Dental College, School of Dentistry, Professor (00298233)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Ora cancer / cancer pain / Neuropathic pain / Trigeminal nerve / COX-2 / COX-3 / Salivary tumor / Differentiation |
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| Research Abstract |
There are resistant to morphine-based pain control due to trigeminal nerve invasion who have diminished QOL due to conditions such as decrease in level of consciousness accompanying use of increasing doses of narcotics. Recently, cyclooxygenase (COX) -2 activation has been reported to play an important role in the centrally generated inflammatory pain hypersensitivity process. Additionally, COX-3 is also related in central sensitization to pain was suggested. So, we examined whether COX-2 and COX-3 are involved in central sensitization to trigeminal nerve stimulation in oral cancer pain. A mouse model of invasive carcinoma of the mandible was used in this study. To examine the expression of COX-2 and COX-3 in the brainstem, immunohistochemical staining of serial sections was performed. But, immunohistochemical staining revealed no expression of COX-2 or COX-3 around the trigeminal nerve. Since this finding probably resulted from the usage of reagents, additional experiments are now in progress.
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