2007 Fiscal Year Final Research Report Summary
Etiology and treatments for gingivitis and gingival overgrowth of the patients with cerebral palsy
| Project/Area Number |
17592156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
ITO Masaki Aichi Gakuin University, School of Dentistry, Lecturer (20213085)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUTA Osamu Aichi-Gakuin University, School of Dentistry, Professor (60090148)
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| Project Period (FY) |
2005 – 2007
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| Keywords | dentistry / gingival overgrowth / cerebral palsy / electron microscope |
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| Research Abstract |
Introduction
The patients with cerebral palsy often take anticonvulsants such as phenytoin (PHT). It is widely accepted that PHT induces gingival overgrowth and reduces bone growth. Oppositely an adverse effect such as calvarial thickening is reported. On the other hand, the parathyroid gland is deeply related to calcium metabolism. The purpose of this research project is to clarify the mechanism of PHT for the gingiva and the parathyroid gland by using electron microscope and establish effective prevention and treatment of PHT-induced gingival overgrowth.
Materials and Methods
This research project consisted of three parts. First, the investigators used electron microscope to observe the resected gingiva from the cerebral palsy patients who were given PHT. Secondly, we investigated to use PHT-induced rats. Their gingiva and the parathyroid glands were observed by electron microscope and body weights, serum phosphate, calcium and PHT concentrations were measured. Finally, we evaluated the relationship between oral hygiene management and fever of the patients in the institution for the patients with severe motor and intellectual disabilities.
Results
The collagen fibers were increased in the hyperplastic gingiva of the cerebral palsy patients. The numbers and areas of the gingival fibroblasts were also increased in the findings of electron microscope.
The mean body weight of PHT-induced rats was significantly less than control rats. The serum phosphate and calcium concentrations of PHT-induced rats were significantly lower than controls. In morphological study by electron microscope, the areas of Golgi apparatus and rough-surfaced endoplasmic reticulum (rough ER) in the gingival fibroblasts of PHT-induced rats significantly decreased compared with controls.
During oral hygiene management by the dental profession, fever up of the severe cerebral palsy patients got decreased in the institution.
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[Presentation] Latex allergy in the outpatient clinic of dentistry.2007
Author(s)
Ito, M., Hiraoka, T., Kato, K., Aso, K., Sugiyama, N. Fukuta, O., Tsuchiya, T.
Organizer
43rd Annual Meeting of Pediatric Society in Central Japan
Place of Presentation
Nagoya
Year and Date
2007-09-02
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The relationship between oral hygiene management and fever of the patients with severe motor and intellectual disabilities.2006
Author(s)
Hiraoka, T., Yamauchi, K., Ito, M., Kawai, T., Fukuta, O., Tsuchiya, T.
Organizer
The 23rd Annual Meeting of the Japanese Society for Disability and Oral Health
Place of Presentation
Sendai
Year and Date
2006-10-21
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Oral health management in a institution for patients with severe motor and intellectual disabilities.2006
Author(s)
Yamauchi, K., Ito, M., Hiraoka, T., Kawai, T., Fukuta, O., Tsuchiya, T.
Organizer
The 23rd Annual Meeting of the Japanese Society for Disability and Oral Health
Place of Presentation
Sendai
Year and Date
2006-10-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Fine structure of phenytoin-induced gingival overgrowth.2005
Author(s)
Ito, M., Oka, Y., Hiraoka, T., Okamoto, T., Fukuta, O., Tsuchiya, T.
Organizer
The 22nd Annual Meeting of the Japanese Society for Disability and Oral Health
Place of Presentation
Showa, Yamanashi
Year and Date
2005-10-15
Description
「研究成果報告書概要(欧文)」より
