2007 Fiscal Year Final Research Report Summary
Mannose-binding lectin gene polymorphism as a risk factor shared in periodontal disease and diabetes mellitus
| Project/Area Number |
17592163
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Meikai University |
|---|
Principal Investigator |
HAYASHI Joichiro Meikai University, School of Dentistry, Associate Professor (50337507)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIN Kitetsu Meikai University, School of Dentistry, Professor (40187555)
HASEGAWA Akihiko Meikai University, School of Dentistry, Professor (20198708)
GOTO Seiichi Meikai University, School of Dentistry, Lecturer (70306299)
NANBA Nanba Meikai University, School of Dentistry, Assistant Professor (40406393)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Keywords | periodontal disease / diabetes mellitus / mannose-binding lectin / gene polymorphism |
|---|
| Research Abstract |
Mannose-binding lectin (MBL) plays an important role in aspects of natural immunity such as complement activation and opsonization. It has been reported that MBL deficiency caused by MBL gene polymorphism is related not only to systemic infections, but also to aggressive periodontitis and diabetes mellitus (DM). In this study, we investigated the effect of MBL gene polymorphism and the serum concentration of MBL on the development and progression of type 2 DM, and on the progression of periodontal disease.
Sixty-two patients with DM and the same number of healthy subjects (HS) were included in this study. MBL codon 54 gene polymorphism and the serum MBL concentration were investigated in each individual The frequency of the MBL gene mutation was not significantly different between DM patients and HS. The serum MBL concentration was significantly lower in the subjects with the mutated gene (mutations) than in those with the wild-type one (wild-type), in both DM and HS groups. Furthermore, periodontal parameters were investigated in the DM patients. There was a significant difference in bleeding on probing between the mutation and wild-type groups of DM patients, the percentage being higher for the former. Especially in the wild-type group, there was a significant positive correlation between the serum MBL concentration and alveolar bone resorption.
In conclusion, our data suggest that MBL gene mutations possibly accelerate inflammation in the periodontal tissue of patients with type 2 diabetes mellitus and that the serum MBL concentration may be a systemic marker of periodontitis.
|
-
-
[Journal Article] Relationship between Mannose-binding Lectin Gene Polymorphism and Type 2 Diabetes Mellitus/Periodontal Disease2008
Author(s)
Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Nanba, Yukihiko, Ochiai, Yoshihiro, Kami, Seiichi, Goto, Akihiko, Hasegawa, Kitetsu, Shin
-
Journal Title
The Journal of Meikai Dental Medicine (in press)
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Hypoxia and Reoxygenation Augment Bone-resorbing Factor Production From Human Periodontal Ligament Cells2007
Author(s)
Hitoshi, Motohira, Joichiro, Hayashi, Junichi, Tatsumi, Masamichi, Tajima, Hiroshi, Sakagami, Kitetsu Shin
-
Journal Title
Journal of Periodontology 78
Pages: 1803-1809
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
[Presentation] Kitetsu Shin : A study of mannose-binding lectin gene polymorphism and its relation to periodontal disease in type 2 diabetes mellitus2007
Author(s)
Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Nanba, Kazuhiro, Yatabe, Toshio, Ohashi, Junichi, Tatsumi, Seiichi, Goto, Akihiko, Hasegawa
Organizer
50th Annual Meeting of the Japanese Society of Periodontology
Place of Presentation
Kanagawa
Year and Date
20070500
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
[Presentation] Kitetsu Shin : Possible association of mannose-binding lectin gene polymorphism with periodontal disease and diabetes mellitus2006
Author(s)
Suguru, Jinzenji, Joichiro, Hayashi, Satomi, Namba, Kaoru, Sugihara, Kanako, Yamamura, Kazuhiro, Yatabe, Seiichi, Goto, Akihiko, Hasegawa
Organizer
49th Annual Meeting of the Japanese Society of Periodontology
Place of Presentation
Chiba
Year and Date
20060400
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Book] 臨床歯周病学2007
Author(s)
申 基てつ
Total Pages
8
Publisher
医歯薬出版
Description
「研究成果報告書概要(和文)」より
-
-
