The study of the association of immune related genotypes with dental caries in Japanese individuals

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17592174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: CHIBA Junko Tohoku University, Graduate School of Dentistry, Preventive, Docent (50197620)
• Co-Investigator(Kenkyū-buntansha): KOSEKI Takeyoshi Graduate School of Dentistry, 大学院・歯学研究科, Professor (80291128) ; OZAWA Yuki Graduate School of Dentistry, 大学院・歯学研究科, Docent (90125518) ; HASHIYADA Masaki Graduate School of Medicine, 大学院・医学系学研究科, Technical expert (40374938)
• Project Period (FY): 2005 – 2007
• Keywords: dental caries / immune related gene / mutans streptococci level / HLA-DRB1 / gene polymorphism / HLA-DQB1

Research Abstract

The literature is replete with evidence supporting that human dental caries, an infectious disease of bacterial origin, can be preventable by mucosal immunization. Recently, significant genetic contribution to caries progression and severity was reported in a twin study. However, it has not been reported to confirm the association of certain immune related genotypes with caries susceptibility. The purpose of the present study was to confirm the association of certain immune related genotypes with caries susceptibility in Japanese individuals. Human leukocyte antigens (HLAs) play an important role in regulating the immune system. A total of 104 children aged 10 yrs (48 children with caries and 56 children without caries) were included to examine the susceptibility to early onset caries. The HLA・DQB1*03/*05 genotypes were significantly associated with dental caries susceptibility (P=0.005, Pc=0.004). The DRB1*04/*15 genotypes were significantly associated with dental caries susceptibility in a total of 135 children aged 13 yrs (75 children with caries and 60 children without caries) (P=0.0045, Pc=0.04). The HLA-DQB1*06/*06 genotypes were significantly associated with dental caries susceptibility in a total of 164 subjects, aged 26 yrs or younger (mean age, 20.4 ±2.2, 98 adolescents with caries and 66 adolescents without caries) (P=O.0027, Pc=0.027). In conclusion, this study using a cohort of a 10-year old, 13-year-old children, and adolescents with and without caries demonstrated the possible effect of specific HLA genotype on dental caries progression.

Research Products

• [Presentation] ヒトのう蝕と唾液中ミュータンス連鎖球菌の関係に対するHLA-DRB1遺伝子型の影響 (2006)
  • Author(s): 千葉潤子、小澤雄樹
  • Organizer: 第9回日本歯科人間ドック学会
  • Place of Presentation: 昭和大学上條講堂東京都品川区
  • Year and Date: 2006-11-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HLA association and caries susceptibility in young Japanese children (2006)
  • Author(s): Chiba J, Ozawa Y
  • Organizer: The 9^<th> Japan academy of dental human dock academic meeting
  • Place of Presentation: at Showa university Kamijo auditorium in Tokyo
  • Year and Date: 2006-11-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 中学生における歯肉炎(歯垢および歯石付着、初経時期との関係について) (2006)
  • Author(s): 小澤雄樹、草野歩、小川裕平、千葉潤子、海老名宥充、加藤徹、小関健由
  • Organizer: 第18回日本口腔衛生学会東北地方会
  • Place of Presentation: 秋田県歯科医師会館秋田市
  • Year and Date: 2006-05-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Gingivitis in young Japanese children (2006)
  • Author(s): Ozawa Y, Kusano A, Ogawa Y, Chiba J, Ebina H, Kato T, Koseki T
  • Organizer: The 18^<th> Japanese society for dental health Tohoku district meeting
  • Place of Presentation: at Akita dental association building in Akita city
  • Year and Date: 2006-05-26
  • Description: 「研究成果報告書概要(欧文)」より