2007 Fiscal Year Final Research Report Summary
INVESTIGATION OF OVERINTAKE AND DRUG INTERACTION OF FUNCTIONAL FOOD COMPONENTS
| Project/Area Number |
17604005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食の安全
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| Research Institution | Okayama University |
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Principal Investigator |
ITO Hideyuki Okayama University, GRADUATE SCHOOL OF MEDICINE, DENTISTRY AND PHARMACEUTICAL SCIENCES, ASSOCIATE PROFESSOR (70253002)
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| Project Period (FY) |
2005 – 2007
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| Keywords | FUNCTIONAL FOOD / DRUG FOOD INTERACTION / CRANBERRY / CYTOCHROME P-450 / URINARY TRACT DESEASE / SAFETY OF FOOD STYLE |
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| Research Abstract |
Functional foods have been used as prevention of several diseases in worldwide. Although its health benefit is noteworthy, the risk assessment of functional foods cannot be disregarded. In this study, I investigated the basic bioavailability of dietary polyphenol and the interaction between food components and medicine.
Cranberry, which is rich in polyphenols including anthocyanins and proanthocyanidins, has been demonstrated to have various effects beneficial to human health including prevention of urinary tract infection. The bioavailability of cranberry polyphenols is little known. Forty-four metabolites in human urine after ingestion of cranberry juice were identified by using LC-ESI-MS/MS. Among metabolites, O-methylated proanthocyanidin A-2 were characterized as a new metabolite.
Hydrolyzable tannins including ellagitannins occur in foods such as berries and nuts. Various biological activities, including antioxidant, antiviral and antitumor activities, have been noted and reported
… More
for ellagitannins, but the absorption and metabolism of purified ellagitannins are poorly understood. I investigated the characterization of urinary and intestinal microbial metabolites in rats after the ingestion of ellagitannin, geraniin. Rat urine sample was separated by column chromatography and/or preparative HPLC, to give seven metabolites, M1-M7. The structures of these metabolites were determined basis on spectroscopic data and chemical evidence. These compounds except for Ml were characterized as ellagitannin metabolites for the first time. Furthermore, among four major metabolites (M1-M4) in urine, M2 showed an antioxidant activity comparable to intact geraniin and related polyphenols.
Interactions between food components and drugs have recently come into focus of interest. The interactions often occur as a result of inhibiting or inducing of the metabolic enzymes, cytochrome P450 (CYP). It is well known that concomitant intake with grapefruit juice increases the concentration of calcium antagonists in human by suppression of CYP3A4 activation. Cranberry juice has been traditionally used for the prevention of urinary tract infection. However, potentiated effects of warfarin following consumption of cranberry juice have been reported. The reasons for the interaction are mainly unknown. I study the inhibitory effects of cranberry extracts and ingredients, and related polyphenols on CYP2C9 and CYP3A4. Consequently, the gut microbial metabolites such as phenolic acids showed no effect. A part of compounds of coumarins, fiavones and flavonols exhibited a strong inhibitory activity.
These results suggested that a part of dietary polyphenols might have the potential to inhibit the metabolism of drugs, so that further study should be investigated to clarify the clinical relevance. Less
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Research Products
(54 results)
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[Journal Article] Characterization and antioxidant properties of oligomeric proanthocyanidin from prunes, dried fruits of Prunus domestica L.2008
Author(s)
Kimura, Y., Ito, H., Kawaji, M., Ikami, T., and Hatano, H.
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Journal Title
Biosci. Biotech. Biochem. (in press)
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Characterization and antioxidant properties of oligomeric proanthocyanidin from prunes, dried fruits of Prunus domestica L2008
Author(s)
Kimura, Y., Ito, H., Kawaji, M., Ikami, T., Hatano, T
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Journal Title
Biosci. Biotech. Biochem (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cowaniin, a C-glucosidic ellagitannin dimer linked through catechin from Cowania mexicana2007
Author(s)
Ito, H., Miyake, M., Nishitani, E., Miyashita, K., Yoshimura, M., Yoshida, T., Takasaki, M., Konoshima, T., Kozuka, M., and Hatano T.
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Journal Title
Chem. Pharm. Bull. 55(3)
Pages: 492-494
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] C-Glucosidic ellagitannin oligomers from Melaleuca squarrosa Donn ex Sm., Myrtaceae2007
Author(s)
Yoshida, T., Ito, H., Yoshimura, M., Miyashita, K., Hatano, T
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Journal Title
Phytochemistry, published online on August 24
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of urinary metabolites of cranberry on biofilm formation by Escherichia coli isolated from a patient with urinary tract infection2007
Author(s)
Kariyama, R., Ohnishi, R., Ito, H., Yoshida, T., Hatano, T., Kokeguchi, S., Mitsuhata, R., Wada, K., Monden, K., Kumon, H
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Journal Title
Bacterial Adherence & Biofilm 20
Pages: 129-133
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cowaniin, a C-glucosidic ellagitannin dialer linked through catechin from Cowania mexicana2007
Author(s)
Ito, H., Miyake, M., Nishitani, E., Miyashita, K., Yoshimura, M., Yoshida, T., Takasaki, M., Konoshima, T., Kozuka, M., Hatano, T
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Journal Title
Chem. Pharm. Bull 55(3)
Pages: 492-494
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice2006
Author(s)
Ohnishi, R., Ito, H., Iguchi, A., Shinomiya, K., Kamei, C., Hatano, T., and Yoshida, T.
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Journal Title
Biosci. Biotech. Biochem. 70(10)
Pages: 2560-2563
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Urinary excretion of anthocyanins in human after cranberry juice ingestion2006
Author(s)
Ohnishi, R., Ito, H., Kasajima, N., Kaneda, M., Kariyama R., Kumon, H., Hatano, T., and Yoshida. T.
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Journal Title
Biosci. Biotech. Biochem. 70(7)
Pages: 1681-1687
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice2006
Author(s)
Ohnishi, It, Ito, H., Iguchi, A., Shinomiya, K., Kamei, C., Hatano, T., Yoshida, T
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Journal Title
Biosci. Biotech. Biochem 70
Pages: 2560-2563
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Urinary excretion of anthocyanins in human after cranberry juice ingestion2006
Author(s)
Ohnishi, R., Ito, H., Kasajima, N., Kaneda, M., Kariyama R., Kumon, H., Hatano, T., Yoshida, T
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Journal Title
Biosci. Biotech. Biochem 70
Pages: 1681-1687
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Metabolites of Gerraniin in Rats2007
Author(s)
Hideyuki Ito, Ayumu Iguchi, Yuriko Yoshida, Tsutomu Hatano
Organizer
3rd International Conference on Polyphenols and Health
Place of Presentation
Kyoto
Year and Date
20071125-28
Description
「研究成果報告書概要(和文)」より
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[Presentation] Antioxidant Proanthocyanidin in Prune2007
Author(s)
Yuka Kimura, Hideyuki Ito, Miyuki Kawaji, Takao Ikami, and Tsutomu Hatano
Organizer
1st International Congress for Medical Use of Functional Foods
Place of Presentation
Tokyo
Year and Date
20071100
Description
「研究成果報告書概要(和文)」より
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[Presentation] Ichthyotoxic and anticarcinogenic effects of triterpenoids, and five new limonoids from Sandoricum koetjape (Meliaceae)2007
Author(s)
Intan, S., Ismail, Ito, H., Mukainaka, T., Higashihara, H., Enjo, F., Tokuda, H., Nishino, H., Yoshida, T
Organizer
12th Asian Chemical Congress international Symposium on Natural Products & Medicinal Chemistry 2007
Place of Presentation
Kuala Lumpur, Malaysia
Year and Date
20070823-25
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Antifungal Constituents from Santalum album of Indian Origin2006
Author(s)
Hideyuki Ito, Tae Hoon Kim, Tsutomu Hatano, Keinosuke Okamoto, Michiko Arita, Hiroshi Kanzaki, Takahisa Machiguchi, and Takashi Yoshida
Organizer
ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
Place of Presentation
Kyoto
Year and Date
20060700
Description
「研究成果報告書概要(和文)」より
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[Presentation] Effect of urinary metabolites of cranberry on biofilm formation by Escherichia coli isolated from a patient with urinary tract infection2006
Author(s)
Kariyama, R., Ohnishi, R., Ito, H., Yoshida, T., Hatano, T., Kokeguchi, S., Mitsuhata, R., Wada, K., Monden, K., Kumon, H
Organizer
The Conference on Bacterial Adherence & Biofilm
Place of Presentation
Tokyo
Year and Date
20060700
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Antibacterial activity of the constituents of Geranium thunbergil against Bacillus cereus2005
Author(s)
Yoshihiro, Yamada, Hidevuki, Ito, Tsutomu, Hatano, Keinosuke, Okamoto, Takashi, Yoshida
Organizer
Annual Meeting of The Pharmaceutical Sciences of Japan, Chu-Shikoku Branch
Place of Presentation
Matsuyama
Year and Date
20051100
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Bioavailability of Tannins (Part 2)2005
Author(s)
Ayumu, Iguchi, Hidevuki, Ito, Tsutomu, Hatano
Organizer
Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Chu-Shikoku Branch
Place of Presentation
Osaka
Year and Date
20050900
Description
「研究成果報告書概要(欧文)」より
