2007 Fiscal Year Final Research Report Summary
Assessments of cognitive function in obstructive sleep apnea patients using functional magnetic resonance imaging and psychological tests
| Project/Area Number |
17605005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
MIYAZAKI Soichiro Shiga University of Medical Science, Sleep Medicine, Professor (20200157)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Miyoshi Shiga University of Medical Science, Radiology, Professor (20127038)
KANAI Hirohiko Shiga University of Medical Science, Psychiatry, Associate Professor (30293830)
IMAI Makoto Shiga University of Medical Science, Psychiatry, Assistant Professor (40335170)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Obstructive sleep apnea / fMRI / Cognitive impairment / Cereberal blood flow / CPAP / Brain volume loss / Frontral cortex / Breath holding |
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| Research Abstract |
Obstructive sleep apnea (OSA) is characterized by diminished upper airway muscle phasic and tonic activation during sleep. Recently, OSA patients show aberrant responses in multiple brain areas, perhaps as a consequence of previously-demonstrated gray matter loss within the frontal cortex, anterior cingulate. In this study, we studied the characteristics of the response of frontal area during breath holding conditions by using functional Magnetic Resonance Imaging (fMRI) and pulse oxymeter in healthy volunteers, and evaluated the impaired cognitive functions in medication-free OSA and control subjects. Average heart rate increased during the breath holding in control subjects and MR signal intensities decreased in frontal lobe. WCST performance exhibited the distinct cognitive impairment in the moderate grade-OSA-patients.
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[Journal Article] A preliminary study on the influence of obstructive sleep apnea upon cumulative parasympathetic system activity2008
Author(s)
Tabata, R., Yin, M., Nakayama, M., Ikeda, M., Hata, T., Shibata, Y., Itasaka, Y., Ishikawa, K., Okawa, M., Miyazaki, S
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Journal Title
Auris Nasus Larynx 35
Pages: 242-246
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Reduced nasal resistance after simple tonsillectomy in patients with obstructive sleep apnea2007
Author(s)
Nakata, S., Mivazaki, S., Ohki, M., Morinaga, M., Noda, A., Sugiura, T., Sugiura, M., Teranishi, M., Katayama, N., Nakashima, T
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Journal Title
American Journal of Rhinology 21
Pages: 192-195
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A preliminary study on application of portable monitoring for diagnosis of structive sleep apnea2005
Author(s)
Yin, M., Mivazaki, S., Itasaka, Y., Shibata, Y., Abe, T., Miyoshi, A., Ishikawa, K., Togawa, K
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Journal Title
Auris Nasus Larynx 32
Pages: 151-156
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effectiveness of surgical treatments for obstructive sleep-related breathing disorders : Upper airway pressure analysis2005
Author(s)
Itasaka, Y., Miyazaki, S., Yin, M., Shibata, Y., Tanaka, T., Ishikawa, KT., Ishikawa, K
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Journal Title
Sleep and Biological Rhythms 3
Pages: 114-121
Description
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