2005 Fiscal Year Final Research Report Summary
Examination Study on Development and Evaluation of Ceramics in Medicine through Control of Nano-interface
| Project/Area Number |
17630008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 企画調査 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Meiji University |
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Principal Investigator |
AIZAWA Mamoru Meiji University, Associate Professor, 理工学部, 助教授 (10255713)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Kunio Kyushu University, Professor, 歯学研究科, 教授 (90202952)
IOKU Koji Tohoku University, Associate Professor, 環境科学, 助教授 (60212726)
OHTSUKI Chikara Nara Institute of Science and Technology, Associate Professor, 物質創成科学, 助教授 (00243048)
KAWASHITA Masakazu Kyoto University, Lecturer, 工学研究科, 講師 (70314234)
NAKAMURA Satoshi Tokyo Medical and Dental University, 生体材料工学研究所, 助手 (40227898)
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| Project Period (FY) |
2005
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| Keywords | Biomaterials / Bioceramics / Nano-structure / Control of nano-interface / Inorganic / organic Hybrid / Cellular Response / Tissue Reaction in vivo / Quality of Life (QOL) |
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| Research Abstract |
There is a rapidly increasing number of patients with diseases of their hard-tissue and, given current demographic trends in today's society with a large number of elderly people ; this is an important global problem with severe financial implications.
In general, hydroxyaptite (HAp) ceramcis, which bonds directly with host bone, is one of a new generation of excellent bioactive materials ; however, HAp has some problems, such as lack of osteoinductivity and relatively inferior mechanical properties as compared with natural bone. In order to overcome the above problems and to provide a high quality of life (QOL) for the aged, we plan to develop novel, high performance biomaterials though control of nano-interface.
Firstly, we performed the examination study on the development and evaluation of ceramics in medicine through control of nano-interface at 2005 including a bibliography. Thus, we have arrived at a concept of "apatite genomics" which the apatite ceramics give an affect to gene expression of cells, such as osteoblast and osteoclasts, based on control of nano-interface between HAp ceramics and cells. We believe that this concept create novel biomaterials with high-performance properties.
In addition, we have organized a session "the development and evaluation of ceramics in medicine through control of nano-interface" of 18^<th> Fall Meeting of The Ceramic Society of Japan at the 28^<th>-29^<th> September 2005 in Osaka, and then our reviews have been published to Journal of Japanese Society for Biomaterials.
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