2018 Fiscal Year Annual Research Report
Tuning the master clock of the brain: Endocannabinoid modulation of the olivo-cerebellar system and animal behavior
| Project/Area Number |
17F17388
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
ウーシサーリ マルリカ・ヨエ 沖縄科学技術大学院大学, 神経活動リズムと運動遂行ユニット, 准教授 (30799656)
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| Co-Investigator(Kenkyū-buntansha) |
IGNATOWSKA-JANKO BOGNA 沖縄科学技術大学院大学, 神経活動リズムと運動遂行ユニット, 外国人特別研究員
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| Project Period (FY) |
2017-11-10 – 2020-03-31
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| Keywords | brain / behavior / endocannabinoid / motor / olivocerebellar system / motion capture / kinematic analysis / modulation |
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| Outline of Annual Research Achievements |
In this year, the experimental protocols and data extraction workflows were developed, allowing conducting the first set of experiments revealing subtle behavioral effects of eCB modulators using clinically relevant (non-overdosing) concentrations. The main experimental sets are currently being executed, and the preliminary results have been presented at international and internal events.
We have expanded the initial behavioral assays from 4 to 10, bringing much broader and complete picture of animal behavior under the examined compound effects. Importantly, we are developing a training program for introducing the method of stress-free animal experimentation to the research community; initial communications in this topic have been received with great enthusiasm both in Japan and abroad.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The project is advancing mostly according to the plan.
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| Strategy for Future Research Activity |
This year, the project will enter in the main data collection phase, as well as solid establishment of the workflows and paradigms leading to future work in this framework.
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Research Products
(5 results)
