2019 Fiscal Year Annual Research Report
Development of a new high-throughput TCR-antigen pair identification method toward cancer immune therapy
Project/Area Number |
17F17389
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
城口 克之 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (00454059)
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Co-Investigator(Kenkyū-buntansha) |
JIN JIANSHI 国立研究開発法人理化学研究所, 生命機能科学研究センター, 外国人特別研究員
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Project Period (FY) |
2017-10-13 – 2020-03-31
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Keywords | イメージング / ピッキング / 細胞相互作用 / T細胞 |
Outline of Annual Research Achievements |
We have been building up a microscopic platform for scanning the real-time cell behaviors, such as cell movement and T cell-target cell interactions. For high-throughput scanning of these behaviors, we have checked that scanning rate of the current system, and found that the speed of stage movement may be enough for the observation of T cell activities. However, in order to link the microscope system to following steps, we found that real-time calculation based on obtained cell images was required. Then, we investigated specifications of a software based on our actual measurements for T cell-target cell interactions. This helps one to combine imaging and following genomic analyses using our cell picking system.
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Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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