Osteoimmunology

2009 Fiscal Year Final Research Report

• Project/Area Number: 17GS0313
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAYANAGI Hiroshi Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (20334229)
• Co-Investigator(Renkei-kenkyūsha): SHINOHARA Masahiro 東京医科歯科大学, 医歯学総合研究科, 助教 (60345733) ; NAKASHIMA Tomoki 東京医科歯科大学, 医歯学総合研究科, 助教 (00346959)
• Project Period (FY): 2005 – 2009
• Keywords: 骨免疫学 / 骨代謝 / 骨疾患 / 自己免疫 / 疾患モデル / 破骨細胞 / 骨芽細胞 / リンパ球

Research Abstract

骨代謝と免疫学の融合分野である骨免疫学の確立を目指した。特に、骨代謝に関与する細胞と免疫担当細胞の分化・活性化メカニズムならびに相互作用を、網羅的解析手法や新規の遺伝子改変マウスを作成することにより解析し、関節リウマチや骨粗鬆症などの疾患治療に対する分子基盤の確立を行った

Research Products

• [Journal Article] IκBζ regulates T_H17 development by cooperating with ROR nuclear receptors (2010)
  • Author(s): Okamoto K., Iwai Y., Oh-hora M., Yamamoto M., Morio T., Aoki K., Ohya K., Jetten A. M., Akira S., Muta T., Takayanagi H.
  • Journal Title: Nature 464 Pages: 1381-1385
• [Journal Article] Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation (2010)
  • Author(s): Hayashi M., Nakashima T., Kodama T., Makrigiannis A P., Toyama-Sorimachi N., Takayanagi, H.
  • Journal Title: Biochem Biophys Res Commun. 393 Pages: 432-438
• [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation (2010)
  • Author(s): Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi S., Calame K., Takayanagi, H.
  • Journal Title: Proc Natl Acad Sci USA 107(7) Pages: 3117-22
• [Journal Article] Osteoimmunology and the effects of the immune system on bone (2009)
  • Author(s): Takayanagi, H.
  • Journal Title: Nat Rev Rheumatol. 5(12) Pages: 667-76
• [Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation (2009)
  • Author(s): Negishi-Koga, T., Takayanagi, H.
  • Journal Title: Immunological Reviews 231 Pages: 241-256
• [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals (2008)
  • Author(s): Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T., Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W., Takayanagi, H.
  • Journal Title: Cell 132 Pages: 794-806
• [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis (2008)
  • Author(s): Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa, K., Latz, E., Golenbock, D.T., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono, K., Kato, S., Saftig, P., Takayanagi, H.
  • Journal Title: Science 319 Pages: 624-627
• [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss (2007)
  • Author(s): Ochi, S., Shinohara, M., Sato, K., Gober H. J., Koga, T., Kodama, T., Takai T., Miyasaka N., Takayanagi H.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 11394-11399
• [Journal Article] Osteoimmunology : shared mechanisms and crosstalk between the immune and bone systems (2007)
  • Author(s): Takayanagi, H.
  • Journal Title: Nat Rev Immunol. 7 Pages: 292-304
• [Journal Article] Regulation of osteoclast differentiation and function by the CaMK-CREB pathway (2006)
  • Author(s): Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T. A., Bito, H., Takayanagi, H.
  • Journal Title: Nat Med. 12 Pages: 1410-1416
• [Journal Article] Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction (2006)
  • Author(s): Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., Cua, D. J., Takayanagi, H.
  • Journal Title: J Exp Med. 203 Pages: 2673-2682
• [Journal Article] Autoamplification of NFATc1 expression determines its essential role in bone homeostasis (2005)
  • Author(s): Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., Takayanagi, H.
  • Journal Title: J Exp Med 202 Pages: 1261-1269
• [Journal Article] NFAT and Osterix cooperatively regulate bone formation (2005)
  • Author(s): Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima K., Takayanagi, H.
  • Journal Title: Nat Med 11 Pages: 880-885
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 20090708-20090710
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: Rheumatology Association, R. O. C. (Taiwan)
  • Place of Presentation: Yilan, Taiwan
  • Year and Date: 2009-12-06
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: ACR/ARHP Scientific Meeting
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2009-10-18
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The Bone & Teeth Gordon Research Conference
  • Place of Presentation: Maine, U.S.A.
  • Year and Date: 2009-07-15
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 3rd Global COE International Symposium, Tokyo Medical and Dental University
  • Place of Presentation: Tokyo
  • Year and Date: 2009-06-10
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 66th KSBMB Annual Meeting, World Trade Center
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-13
• [Presentation] (2009)
  • Author(s): 高柳広
  • Organizer: The 3rd New York Skeletal Biology and Medicine Conference, Mount Sinai School of Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2009-04-30
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: Annual Meeting of Korean Endocrine Society
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-08
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: 2008 ACR Basic Research conference
  • Place of Presentation: San Francisco
  • Year and Date: 2008-10-24
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: The 13th Congress of the Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-23
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: 2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2008-06-11
• [Presentation] (2008)
  • Author(s): 高柳広
  • Organizer: International Bone & Mineral Society Davos Workshops
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2008-03-10
• [Presentation] Meet-the-Professor Session (2007)
  • Author(s): 高柳広
  • Organizer: The 29th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Honolulu, U.S.A.
  • Year and Date: 2007-09-19
• [Presentation] (2007)
  • Author(s): 高柳広
  • Organizer: 2nd Conference on Skeletal Biology and Medicine
  • Place of Presentation: New York, U.S.A.
  • Year and Date: 2007-04-26
• [Presentation] (2007)
  • Author(s): Hiroshi Takayanagi
  • Organizer: INSERM The 2nd Annual Meeting of PRO-A, Institut Curie
  • Place of Presentation: Paris, France
  • Year and Date: 2007-01-25
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: International Conference on Progress in Bone and Mineral Research on the occasion of the Awarding of the 2006 International Research Prize
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-11-17
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: 3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting of the Australian & New Zealand Bone & Mineral Society
  • Place of Presentation: Port Douglas, Australia
  • Year and Date: 2006-10-23
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: The 28th Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Philadelphia, U.S.A.
  • Year and Date: 2006-09-15
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: The 2005 Gordon Conference on Bones and Teeth
  • Place of Presentation: University of New England, U.S.A.
  • Year and Date: 2006-07-11
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: 1st International Conference on Osteoimmunology
  • Place of Presentation: Crete, Greece
  • Year and Date: 2006-05-31
• [Presentation] (2006)
  • Author(s): 高柳広
  • Organizer: International Symposium on Osteoporosis, Korean Society of Osteoporosis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-04-08
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: 5th Global Arthritis Research Network (GARN)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2005-09-16
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: European Calcified Tissue Society and International Bone and Mineral Society (ECTS, IBMS)
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2005-06-26
• [Presentation] (2005)
  • Author(s): 高柳広
  • Organizer: Annual European Congress of Rheumatology "EULAR 2005"
  • Place of Presentation: Vienna
  • Year and Date: 2005-06-08
• [Book] 5. 骨・関節-b. 破骨細胞、炎症・再生医学事典 (2009)
  • Author(s): 高柳広
  • Total Pages: 247-250
• [Book] Cytokine and growth factor regulation of osteoclastogenesis(The Skeletal System) (2009)
  • Author(s): Takayanagi, H.
  • Total Pages: 263-275
• [Book] Osteoimmunology と破骨細胞 医学部のあゆみ 別冊 骨粗鬆症-臨床と研究の最新動向 (2008)
  • Author(s): 高柳広
  • Total Pages: 37-45
• [Book] 骨免疫学と疾患、免疫応答と免疫病態の統合的分子理解(編者 : 谷口維紹、山本一彦) (2007)
  • Author(s): 高柳広
  • Total Pages: 217-228
  • Publisher: 南光堂
• [Book] NFATc1による破骨細胞分化のメカニズム、Annual Review 免疫2007(編集 : 奥村康、平野俊夫、佐藤昇志) (2006)
  • Author(s): 篠原正浩, 高柳広
  • Total Pages: 317-325
  • Publisher: 中外医学社
• [Book] RA関節破壊における破骨細胞の役割、リウマチ・膠原病最新トピックス(竹原和彦、佐藤伸一、桑名正隆 編著) (2005)
  • Author(s): 高柳広
  • Total Pages: 49-54
  • Publisher: 診断と治療社
• [Book] 骨研究がわかる、実験医学 (2005)
  • Author(s): 高柳広 <編集>
  • Publisher: 羊土社
• [Remarks] ホームページ等
  • URL: http://www.osteoimmunology.com/