2020 Fiscal Year Final Research Report

Development of novel adenovirus vectors through the analysis of the virus with mammalian cells

Research Project

Project/Area Number	17H00863
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Biomedical engineering/Biomaterial science and engineering
Research Institution	Osaka University
Principal Investigator	Hiroyuki Mizuguchi 大阪大学, 薬学研究科, 教授 (50311387)
Project Period (FY)	2017-04-01 – 2021-03-31
Keywords	ウイルス / 遺伝子 / 癌 / 免疫学 / バイオテクノロジー
Outline of Final Research Achievements	In this study, we have done several basic studies about adenoviruses (Ad) in terms of viral replication, microRNA, immune responses, etc. And then, through such basic studies, we tried to develop several types of novel recombinant Ad vectors for gene therapy, vaccine, viral therapy, etc. We also developed novel Ad vectors having gene editing functions.
Free Research Field	分子生物学
Academic Significance and Societal Importance of the Research Achievements	本研究は、Adと宿主の攻防を理解し、研究代表者が有する世界で最先端のAdベクター改変技術を駆使することで、新しい視点からベクター開発（改良）と関連する応用研究を進めるものであり、独創性が高く、学術的意義が大きい。また、日本独自の高性能ベクター開発は、その汎用性の観点から国益を考えたうえでも最重要研究課題の一つであり、その社会的意義は極めて大きい。