2019 Fiscal Year Annual Research Report
Developing mouse models of inflammation-driven invasive gastric cancer to reveal novel therapeutic targets
| Project/Area Number |
17H01399
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| Research Institution | Kanazawa University |
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Principal Investigator |
NICHOLAS BARKER 金沢大学, その他部局等, リサーチ・プロフェッサー (30787651)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | gastric cancer / mouse model / inflammation / Lgr5 / organoid |
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| Outline of Annual Research Achievements |
Our mechanistic understanding of gastric cancer remains limited, hampering the development of more effective therapeutics.
Using proprietary new mouse models and ex vivo culture assays, we will i) evaluate the contribution of Lgr5-expressing corpus stem cells to inflammation-driven cancer initiation ii) generate the first inflammation driven mouse models of metastatic gastric cancer to functionally evaluate Lgr5-expressing tumor cells as cancer stem cells iii) evaluate the contribution of TCGA derived driver mutations such as RhoA and RNF43 to in vivo gastric cancer formation.
These research avenues will deliver invaluable mechanistic insight into gastric cancer progression and will reveal novel opportunities for therapeutic intervention.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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