2023 Fiscal Year Final Research Report

Epidemiologic research on the association between dietary habits, blood pressure, and metabolomics of blood and urine.

Research Project

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Project/Area Number	17H01553
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Epidemiology and preventive medicine
Research Institution	Shiga University of Medical Science
Principal Investigator	Ueshima Hirotsugu 滋賀医科大学, NCD疫学研究センター, 特任教授 (70144483)
Co-Investigator(Kenkyū-buntansha)	三浦克之滋賀医科大学, 医学部, 教授 (90257452) 中川秀昭金沢医科大学, 総合医学研究所, 教授 (00097437) 坂田清美岩手医科大学, 医学部, 教授 (50225794) 斉藤重幸札幌医科大学, 保健医療学部, 教授 (60253994) 奥田奈賀子京都府立大学, 生命環境科学研究科, 教授 (80452233)
Project Period (FY)	2017-04-01 – 2022-03-31
Keywords	国際共同研究 / メタボローム / 疫学 / 公衆衛生学 / 非感染性疾患 / 循環器疾患 / 血圧
Outline of Final Research Achievements	The INTERLIPID study (1412 participants in 5 cohorts: 4 Japanese in Japan and 1 Japanese American in Hawaii) is a sub-study of the INTERMAP study (4,680 men and women aged 40-59 years in 17 cohorts from China, Japan, UK, and USA), an international collaboration on nutrition and blood pressure conducted in 1996-99. Metabolomic analysis of their fasting serum samples was conducted at the collaborating institution, Imperial College London, U.K. Although there were delays due to COVID-19, metabolomic measurements by NMR and LC-MS were eventually completed. Metabolome and biomarker searches related to Japan-US differences, diet/lifestyle, and cardiovascular disease were conducted, and a frame of database infrastructure was established that young researchers can analyze in the future.
Free Research Field	疫学、公衆衛生学、循環器疾患、血圧
Academic Significance and Societal Importance of the Research Achievements	本研究では、英国Imperial College Londonで測定済みのINTERMAP尿中代謝物データベースに、新たに日本主導のINTERLIPID対象者の血中代謝物データベースを付加した点に学術的意義がある。また、この長年の4か国間の国際共同研究を通じて培ってきた歴史と研究者間の信頼関係に社会的意義がある。今後、メタボロームをはじめとした栄養、血圧、循環器疾患に関する新たな解析を、若手研究者らが行うためのデータベース整備および国際人材交流を通じたさらなる研究発展に繋がる基盤を構築できたと考えている。