2020 Fiscal Year Final Research Report
Elucidation of vagal mechanism underlying glucose homeostasis
| Project/Area Number |
17H01565
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | 臓器間ネットワーク / 糖代謝 / 恒常性 / 膵β細胞 / インスリン / 糖尿病 / 肥満 |
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| Outline of Final Research Achievements |
Neuronal relay systems play critical roles in communicating metabolic information among organs/tissues and maintaining glucose homeostasis at the whole-body level. We have further advanced our previous achievements. This study showed the molecular mechanisms of neuron-derived pancreatic β cell proliferation. First, combination of acetylcholine and PACAP induced β cell proliferation. In addition, we showed the FoxM1 pathway in β cells to enhance cell cycle, leading to beta cell proliferation. Furthermore, stimulation of abdominal vagal nerve per se was shown to promote both insulin secretion acutely and β cell proliferation chronically.
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| Free Research Field |
代謝学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、迷走神経による膵β細胞制御の分子機序や組織学的機序を明らかとし、多臓器生物が多臓器生物の糖代謝恒常性の仕組みの理解を深める学術的意義を有する。また、その解明に種々の遺伝子改変モデルや新規研究手法を開発し、研究手法の発展にも寄与した。さらに、膵β細胞からのインスリン分泌促進や膵β細胞量の増加につながる成果は、糖尿病の予防法・治療法開発につながることが期待され、医学的・社会的意義を包含していると考えられる。
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