Group SUMOylation in response to damage of genome and proteome in cells

2022 Fiscal Year Final Research Report

• Project/Area Number: 17H01878
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Kumamoto University
• Principal Investigator: Saitoh Hisato 熊本大学, 大学院先端科学研究部(理), 教授 (50211925)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: 核 / クロマチン / 膜ベシクル / 微小核 / がん化 / 細胞増殖 / シグナル伝達 / 損傷応答

Outline of Final Research Achievements

Quality control of the genome and proteome in the cell nucleus of eukaryotic cells, including humans, is closely related to cell fate determination and cell death. It is important to understand the basis of their molecular regulation. Protein network regulation, including post-translational modifications of proteins, is one of the molecular regulatory bases. In the early stages of this study, we focused on SUMOylation among post-translational　modifications, but later we expanded our analysis to broad aspects of cellular components, including genome, protein as well as phospholipid membrane. As a result, multiple experimental systems have been set up to determine how human cells initiate molecular responses to the internal and external environment, providing insights into multiple signaling regulatory systems in human cells.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

学術的には分子生物学の基盤知識、特に細胞核やクロマチンの制御に関する基礎的な知見を深化・拡張した点は意義があると考えている。また、社会的にはゲノムやプロテオームの制御を活用した保健医療や環境科学の諸分野における技術開発の知的基盤を構築することに貢献できたと考えている。