2020 Fiscal Year Final Research Report
Development of computational biomechanics of the gastrointestinal system
| Project/Area Number |
17H02075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kobe University (2018-2020)
Tohoku University (2017) |
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Principal Investigator |
Imai Yohsuke 神戸大学, 工学研究科, 教授 (60431524)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | 消化器系バイオメカニクス / 計算バイオメカニクス / 計算力学 / 生体シミュレーション / 医工学 |
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| Outline of Final Research Achievements |
We developed a numerical model of gastric flow using computational fluid dynamics, medical imaging, and electrophysiology. We showed that impaired coordination between antral contraction and pyloric closure can result in delayed gastric emptying and bile reflux. We also found that slow wave velocity changed with interstitial cells of Cajal loss and aging, resulting in changes in emptying rate.
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| Free Research Field |
計算生体流体力学
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| Academic Significance and Societal Importance of the Research Achievements |
潰瘍や癌がないにも関わらず胃痛や胸やけを訴える疾患を「機能性ディスペプシア」と呼び，消化管運動障害がその原因と考えられている．しかしながら，胃内部の食物流動を観察することは困難であり，消化管運動と食物流動の関係は十分明らかでない．本研究では，胃内部で生じる食物流動のコンピュータシミュレーション（数値流体力学解析）を実現した．
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