2020 Fiscal Year Final Research Report
Efficient fluorescence detection of single molecules in liquid by using optical nanofibers
| Project/Area Number |
17H02741
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | ナノデバイス / 光ファイバ / ナノ粒子 / 化学分析 |
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| Outline of Final Research Achievements |
In nanophotonic devices, substantial enhancement of optical field is realized by confining photons in a small area, which enables strong light-matter interaction. In this research, we study optical nanofibers that provide efficient optical coupling between the fluorescent two level systems (molecules, nanoparticles, etc) and optical fiber mode for the use in aqueous media. The main results are as follows: (1) A single-ended optical nanofibers were fabricated and applied to the nematode C. elegans. (2) The surface state and optical (and spin) properties of gold or diamond nanoparticles were quantified for their better integration with nanofibers. In addition, pH dependence of nanodiamond spin properties was determined. (3) Temperature sensing of cells and nematodes was realized using fluorescent nanodiamonds.
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| Free Research Field |
ナノフォトニクス、ナノバイオ
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、量子エレクトロニクス分野で開発してきたナノ光ファイバデバイスを水溶液中での利用に耐えうるものとしようとするものである。このナノ光ファイバは空気中などでは超高効率蛍光検出が可能であり、その詳細な動作特性も明らかとなっていたが、本研究により、ナノ光ファイバの溶液中利用における動作特性の理解が進展した。また、細胞や線虫と言った実際的な生体試料に適用した際の利用例を、細胞温度測定という観点から部分的に示すことができた。将来的には、生体内での温度モニタリングなどの技術にもつながると期待される。
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