2020 Fiscal Year Final Research Report
Preparation of multi-responsive nanocarrier by near infrared
Project/Area Number |
17H03071
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Polymer chemistry
|
Research Institution | University of Hyogo |
Principal Investigator |
Yusa Shin-ichi 兵庫県立大学, 工学研究科, 准教授 (00301432)
|
Co-Investigator(Kenkyū-buntansha) |
岩崎 泰彦 関西大学, 化学生命工学部, 教授 (90280990)
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Keywords | フラーレン / 高分子ミセル / 感温性 / 近赤外 / 精密ラジカル重合 / 光熱変換 / 刺激応答性 / 薬物放出 |
Outline of Final Research Achievements |
We have prepared novel hydrophilic copolymers that can dissolve hydrophobic fullerenes in water. Fullerenes can efficiently convert near-infrared light energy into heat. The hydrophilic copolymers have a thermo-responsive unit. Although the thermo-responsive unit cannot dissolve in water at room temperature, it can dissolve in water at high temperature. Water-soluble complexes were formed with the copolymers and fullerenes. It was confirmed that the complex aqueous solutions generated heat upon irradiation of near-infrared light. Also active oxygen which kills the cancer cells can be generated from fullerenes in the complex upon light irradiation. Furthermore, it was confirmed that drugs such as anticancer drugs encapsulated into the complex at room temperature can be released from the complex upon heating.
|
Free Research Field |
高分子化学
|
Academic Significance and Societal Importance of the Research Achievements |
生体適合性高分子を用いることで、疎水性のフラーレンを水に可溶化する新しい方法を開発した。高分子とコンプレックスを形成することでフラーレンを水に可溶化した。コンプレックスの水溶液に光を照射すると活性酸素を発生し、周囲の細胞を殺傷するためがん細胞などにダメージを与えられる。さらに、コンプレックス内に取り込ませた抗がん剤を、加熱をトリガーとして制御放出できた。本研究で開発したコンプレックスは、光線力学的療法と薬物の制御放出を組み合わせた、新しいがん治療法に繋がると期待される。
|