2020 Fiscal Year Final Research Report
Three-dimensional biohybrid fabrication with microgels by relatively diamagnetic assembly
| Project/Area Number |
17H03202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 大介 信州大学, 学術研究院繊維学系, 准教授 (90547019)
加納 徹 東京理科大学, 工学部情報工学科, 助教 (40781620)
小関 道彦 信州大学, 学術研究院繊維学系, 教授 (50334503)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | 相対的反磁性アセンブリ / ゲル微粒子 / ソフトアクチュエータ |
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| Outline of Final Research Achievements |
If a three-dimensional fabrication method with high biocompatibility in a micro-enclosed space is developed, it would bring us much closer to the realization of "organ-on-chip" that can create tissues and organs with cells on a substrate. Based on the novel concept of electrostatically attaching two types of positively and negatively charged microgels, we developed a highly biocompatible biohybrid 3D fabrication method by using the original method that aggregate non-magnetic particles with a magnetic field. Furthermore, by adding thermo-responsive polymers to the microgels, it was confirmed that the microgel aggregate functioned as a heat-shrinkable actuator.
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| Free Research Field |
バイオエンジニアリング，生体医工学，マイクロナノメカトロニクス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，光硬化剤によらない新たな3次元造形法を提案し実証した．本手法は，生体適合性が高く，ソフトなゲル構造体を構築できる．さらに熱応答性を付与することでソフトアクチュエータとしても活用可能である．近年注目を集める”Organ-on-chip”(基板上に各種臓器の微小な組織を構築し集積化したもの)等の開発に向けて，新たな手段を提供できるだろう．
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