2020 Fiscal Year Final Research Report
Photosynthetic water oxidation: Molecular mechanism of proton-coupled electron transfer
| Project/Area Number |
17H03662
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉浦 美羽 愛媛大学, プロテオサイエンスセンター, 准教授 (80312255)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | 生物物理 / 光合成 / 赤外分光 / 水分解 / 電子移動 |
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| Outline of Final Research Achievements |
We studied the molecular mechanism of proton-coupled electron transfer in photosynthetic water oxidation mainly using infrared spectroscopy, quantum chemical calculations, and site-directed mutagenesis. The process of proton and water transfer as well as electron transfer was detected, and proton and water pathways in photosystem II proteins were identified. In addition, the formation process of the Mn4CaO5 cluster, which is a catalytic center of water oxidation, was observed. Furthermore, we found novel mechanism of light-induced amino acid conversation at the ligands of the Mn ions.
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| Free Research Field |
生物物理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、天然の光合成における水分解・酸素発生反応の分子機構、およびその触媒部位であるMn4CaO５クラスターの構築過程について多くの知見が得られた。現在人類が直面するエネルギー問題、地球温暖化問題の解決の鍵を握る、人工光合成系の構築および実用化のためには、高効率な水分解触媒の開発が急務であり、本研究で得られた知見は、こうした人工水分解触媒の設計の基本原理を与え、大きく社会に貢献するものであると考えている
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