Interaction between embryo and maternal tissues during the anterior-posterior axis formation of the mouse embryo

2020 Fiscal Year Final Research Report

• Project/Area Number: 17H03689
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: National Institute for Basic Biology
• Principal Investigator: Fujimori Toshihiko 基礎生物学研究所, 初期発生研究部門, 教授 (80301274)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: マウス / 胚軸 / 胚体外組織 / 子宮

Outline of Final Research Achievements

The mouse blastocyst implants on the mesometrium side of the uterus, and future placenta is formed on the mesometrium side. During the mouse development, the future anterior side is formed after the migration of the visceral endoderm (VE) from the distal side of the cylinder-shaped embryo at 5.5 day after the fertilization. Formation of the body axis in cultured embryos has been reported, and these results indicate that embryos can autonomously form body axes. However, the significance of the interaction with the uterine environment on the embryonic axis formation is unclear. The relationship between the axis of the uterus and the anterior-posterior axis of the embryo is quantitatively measured in the pregnant mouse uterus, and the factors that are regulating this relationship are searched.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

哺乳類胚発生の大きな特徴は、母胎内で発生が進むことにある。マウス胚が培養下で自律的に体軸形成できることが示されている。一方で、子宮内において胚軸と子宮軸が関連することが示唆されていた。そこで、母体との相互作用は栄養供給に限らず、胚軸形成についても重要な意義を持つことを検証するという点で本研究は学術的な意義が大きい。