2020 Fiscal Year Final Research Report
Mechanisms of adipocytokine control of cardiovascular diseases through the regulation of multi organ network
| Project/Area Number |
17H03918
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Keywords | 循環器疾患 / アディポサイトカイン |
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| Outline of Final Research Achievements |
Visceral obesity is the major risk factor for cardiovascular diseases (CVD). Adipose tissue-derived cytokine (adipocytokine) links visceral obesity to pathogenesis of CVD. This study aimed to explore the adipocytokine regulatory mechanisms of CVD specifically focusing on blood vessels, heart, and brain. We for the first time revealed that (1) adipocytokine chemerin may mediate the development of pulmonary hypertension, (2) chemerin mediates systemic hypertension through the action on central nerves, (3) chemerin affects the contractility and beating of the heart.
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| Free Research Field |
循環薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
生活習慣の欧米化の結果、西洋の先進国だけでなく、我が国においても肥満による心血管疾患は増加の一途を辿り、医療費の増大や死亡率の増加など様々な問題の原因となっている。よって、疾患の新たな病態機序の解明に基づく新薬や新規治療法の開発は喫緊の課題である。本研究で明らかにしたアディポサイトカインによる血管を中心とした多臓器に対する作用を介した心血管疾患の新たな病態制御機構は肥満による循環器疾患の新規治療法開発の礎となる可能性がある。
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