2019 Fiscal Year Final Research Report
Development of Radicalomics Technique
| Project/Area Number |
17H03977
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | ラジカル / 蛍光検出 / 高分子 |
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| Outline of Final Research Achievements |
Our body produces reactive oxygen species (ROS). ROS oxidizes lipids and proteins, and these oxidized products induce inflammation. However, the detection method of these radicals, which are intermediates of these oxides, is limited because of their quite high reactivity. Hence, the purpose of this study was to develop and evaluate a fluorescent probe that detects protein and DNA-derived radicals. As a result, we succeeded in detecting not only protein radicals but also DNA radicals.
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| Free Research Field |
薬学
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| Academic Significance and Societal Importance of the Research Achievements |
我々の体では、常に酸化障害が生じており、例えば活性酸素が生成する。これら活性酸素は、脂質や蛋白質など、より大きな分子を酸化障害し、その機能を消失させる。今回我々は、この酸化障害のラジカル中間体の検出に成功した。このことは、生体内で生じている酸化障害のメカニズム解明に役立つのみでなく、その阻害を目的とした創薬研究を加速することに大いに貢献できるであろう。
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