Practical application of biomonitoring method for understanding the exposure of pyrethroid for home use

2019 Fiscal Year Final Research Report

• Project/Area Number: 17H04132
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Nagoya University
• Principal Investigator: Ueyama Jun 名古屋大学, 医学系研究科(保健), 准教授 (00397465)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: ピレスロイド系殺虫剤 / バイオモニタリング

Outline of Final Research Achievements

Pyrethroid (PYR) is one of the main insecticides used not only in agriculture fields but also household environments and public places. We focused on the exposure assessment of transfluthrin, metofluthrin, profluthrin, and the other PYRs. A sensitive and efficient procedure for the high-throughput determination of nine urinary metabolites of pyrethroids such as 2,3,5,6-tetrafluorobenzyl alcohol (FB-Al), 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol (CH3-FB-Al), 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol (CH3OCH2-FB-Al), and 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (HOCH2-FB-Al) has been developed using GC-MS/MS.Moreover, we revealed that exposure level to some PYRs has increased over the past decade, and that children are exposed to higher levels of hygiene-PYRs in summer than in winter.

Free Research Field

環境衛生学

Academic Significance and Societal Importance of the Research Achievements

これまでに一般生活者集団の尿から新規に開発されたピレスロイド系殺虫剤の曝露マーカーである尿中代謝物を定量分析した報告はない。本研究によって一般生活者集団から曝露マーカーをモニタリングできるようになり、日常的なピレスロイド系殺虫剤の曝露レベルを個人レベルで把握することを可能にした。この成果は、ピレスロイド系殺虫剤を含有する虫ケア商品などの、安全でかつ有効な使用に向けた使用方法あるいは法規制の立案に貢献できるものと思われる。