多能性幹細胞由来心筋細胞の細胞周期制御のための統合的アプローチ

Products Report

• Project/Area Number: 17H04176
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Yoshida Yoshinori 京都大学, iPS細胞研究所, 准教授 (20447965)
• Project Period (FY): 2017-04-01 – 2021-03-31

Research Products

• [Journal Article] ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation (2024)
  • Author(s): Fujiwara Yuya、Miki Kenji、Deguchi Kohei、Naka Yuki、Sasaki Masako、Sakoda Ayaka、Narita Megumi、Imaichi Sachiko、Sugo Tsukasa、Funakoshi Shunsuke、Nishimoto Tomoyuki、Imahashi Kenichi、Yoshida Yoshinori
  • Journal Title: Stem Cell Reports Volume: 7 Pages: 231
  • DOI: 10.1038/s42003-024-05809-2
  • Peer Reviewed / Open Access
• [Journal Article] CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells (2024)
  • Author(s): Nakanishi-Koakutsu Misato、Miki Kenji、Naka Yuki、Sasaki Masako、Wakimizu Takayuki、Napier Stephanie C.、Okubo Chikako、Narita Megumi、Nishikawa Misato、Hata Reo、Chonabayashi Kazuhisa、Hotta Akitsu、Imahashi Kenichi、Nishimoto Tomoyuki、Yoshida Yoshinori
  • Journal Title: Communications Biology Volume: 7 Pages: 231
  • DOI: 10.1038/s42003-024-05809-2
  • Peer Reviewed / Open Access
• [Journal Article] Generation of 3D-Multicellular Human iPSC-Heart Organoids for the Noninvasive Assessment of Cardiac Fibrosis (2024)
  • Author(s): Lucena-Cacace A, Tian Y, Yoshida Y
  • Journal Title: Methods in Molecular Biology Volume: 2803 Pages: 35-48
  • DOI: 10.1007/978-1-0716-3846-0_3
  • Open Access
• [Journal Article] Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart (2023)
  • Author(s): Kasamoto Manabu、Funakoshi Shunsuke、Hatani Takeshi、Okubo Chikako、Nishi Yohei、Tsujisaka Yuta、Nishikawa Misato、Narita Megumi、Ohta Akira、Kimura Takeshi、Yoshida Yoshinori
  • Journal Title: Stem Cell Reports Volume: 18 Pages: 1672-1685
  • DOI: 10.1016/j.stemcr.2023.06.006
  • Peer Reviewed / Open Access
• [Presentation] SMAD3 Mediates the Specification of Human-Induced Pluripotent Stem Cell-Derived Epicardium into Progenitors for the Cardiac Pericyte Lineage (2024)
  • Author(s): Yutaro Miyoshi, Yoshinori Yoshida
  • Organizer: 第88回日本循環器学会学術集会
• [Presentation] Machine Learning-Based Drug Screening System Using Human iPS Cell-Derived Cardiomyocytes and Cardiac Tissues to Discover Novel Therapies for Drug-Induced Cardiotoxicity (2024)
  • Author(s): Shunsuke Funakoshi, Masako Sasaki, Shigeru Kondo, Yuki Naka, Kenichi Imahashi, Yoshinori Yoshida
  • Organizer: 第88回日本循環器学会学術集会
• [Presentation] Developing Efficient Myocardial Reconstruction Therapy Using iPS Cells (2024)
  • Author(s): Yoshinori Yoshida
  • Organizer: Dubai Stem Cell Congress 2024
  • Int'l Joint Research / Invited
• [Presentation] The Application of Multimodal Analysis to Cardiac Biopsy Samples Facilitates a Quantitative and Mechanistic Framework for Investigating Cardiac Fibrosis (2024)
  • Author(s): Yoshinori Yoshida
  • Organizer: 第88回日本循環器学会学術集会
• [Presentation] グラフト形成効率の高い心筋細胞移植法の開発 (2024)
  • Author(s): 吉田善紀
  • Organizer: 第23回日本再生医療学会
• [Presentation] Generation of mature epicardium derived from human-induced pluripotent stem cells via inhibition of mTOR signaling (2023)
  • Author(s): Tian Yu, Antonio Lucena-Cacace, Yoshinori Yoshida
  • Organizer: ISSCR 20th Annual Meeting
  • Int'l Joint Research
• [Presentation] Generation of cardiac cells and tissues from iPS cells for biomedical applications (2023)
  • Author(s): Yoshinori Yoshida
  • Organizer: CARDIOVASCULAR BIOENGINEERING (CVBE) SYMPOSIUM 2023
  • Int'l Joint Research / Invited
• [Presentation] 細胞周期制御による高効率心筋再建治療法の開発 (2023)
  • Author(s): 吉田善紀
  • Organizer: 第27回日本心不全学会学術集会
• [Presentation] Efficient Reconstruction of the Failing Heart Using iPS Cells (2023)
  • Author(s): Yoshinori Yoshida
  • Organizer: ADSOC 2023 Bone Marrow Transplant & Cellular Therapy Congress
  • Int'l Joint Research / Invited
• [Presentation] Cardiac pharmacology study using human iPS cell-derived mature cardiac tissues. (2023)
  • Author(s): 吉田善紀
  • Organizer: 第97回日本薬理学会年会
  • Invited
• [Patent(Industrial Property Rights)] 心筋細胞増殖促進剤及びその利用 (2024)
  • Inventor(s): 吉田善紀、羽溪健、笠本学、舟越俊介
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許第7427223号
• [Patent(Industrial Property Rights)] 心筋細胞増殖促進剤及びその利用 (2023)
  • Inventor(s): 吉田善紀, 羽渓健, 鈴木涼介, 川端慎吾
  • Industrial Property Rights Holder: 国立大学法人京都大学, 三洋化成工業株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許第7241358号