2019 Fiscal Year Final Research Report
Investigation of omics analysis and detection of biomaker to patients with airway disease progression and sleep disturbance
| Project/Area Number |
17H04182
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Chin Kazuo 京都大学, 医学研究科, 特定教授 (90197640)
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| Co-Investigator(Kenkyū-buntansha) |
松田 文彦 京都大学, 医学研究科, 教授 (50212220)
田原 康玄 京都大学, 医学研究科, 准教授 (00268749)
松本 久子 京都大学, 医学研究科, 准教授 (60359809)
若村 智子 京都大学, 医学研究科, 教授 (40240452)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 睡眠呼吸障害 / 睡眠時無呼吸 / 高血圧 / 糖尿病 / 肺機能低下 / メタボローム |
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| Outline of Final Research Achievements |
A cross-sectional study evaluated 7051 community participants (Nagahama Cohort) with wrist actigraphy and nocturnal oximetry. Moderate-to-severe sleep disordered breathing (SDB). (men/premenopausal women/postmenopausal women; 23.7/1.5/9.5%, respectively) was associated with a higher risk of diabetes in premenopausal women (OR 28.1; p < 0.001) and postmenopausal women (OR 3.25; p < 0.001), but notin men. Moderate-to-severe SDB was associated with a higher risk of hypertension in men (OR 3.11; 95%CI 2.23-4.33; p < 0.001), premenopausal women (OR 3.88; 95%CI 1.42-10.6; p = 0.008), and postmenopausal women (OR 1.96; 95%CI 1.46-2.63; p < 0.001). Short sleep duration was not associated with diabetes or hypertension. The associations of obesity with diabetes or hypertension were indirectly mediated by SDB (24.0% and 21.5%, respectively), with possible sex differences emerging (men/women; 15.3/27.8% and 27.0/16.9%, respectively). Pulmonary function test and metabolome analysis were also done.
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| Free Research Field |
呼吸器内科
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| Academic Significance and Societal Importance of the Research Achievements |
京都大学と滋賀県長浜市が協力の元、約1万人規模で、睡眠呼吸障害(ほとんどが睡眠時無呼吸）の肺機能低下、高血圧、糖尿病などの生活習慣病との関連と影響を検討しています。アジア最大、世界でも現状2位の規模で調査が行われています。中等度以上の睡眠呼吸障害の頻度は，男性23.7％，閉経後女性9.5％，閉経前女性1.5％と明確な性差が認められました。また、中等度以上の睡眠呼吸障害は高血圧の頻度とは男女とも有意な関連が認められましたが、糖尿病については女性のみに有意な関連が認められました。
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