2021 Fiscal Year Final Research Report

Roles of dendritic cells in early detection of graft rejection and their dynamic influences on AKI biomarkers

Research Project

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Project/Area Number	17H04333
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Urology
Research Institution	Tokyo Medical University
Principal Investigator	Takuya Ueno 東京医科大学, 医学部, 兼任講師 (00296469)
Co-Investigator(Kenkyū-buntansha)	岩本整東京医科大学, 医学部, 准教授 (00338831) 竹内裕紀東京薬科大学, 薬学部, 准教授 (20439912) 高原史郎大阪大学, 医学系研究科, 招へい教授 (70179547) 新見正則帝京大学, 医学部, 准教授 (80198415) 中村有紀東京医科大学, 医学部, 講師 (50349487)
Project Period (FY)	2017-04-01 – 2020-03-31
Keywords	拒絶反応 / イメージング / 急性腎障害
Outline of Final Research Achievements	Due to the lack donor pool, to detect graft rejection in earlier time points should be mandatory and also high accuracy is preferable. Therefore, we aimed to investigate to develop a new therapeutic system to detect it with using measurements of acute kidney injury (AKI) biomarkers such as NGAL and L-FABP In the current study. Additionally, we determined a new role of Dendritic cells as a therapeutic target in transplantation instead of T cell targeted therapy, which would allow us to lead to prolong graft survival in a safety manner. These work have been already reported in both several international congress (i.e. American Transplant Congress, E-ISFA) and papers (Curr Protein Pept Sci. 2019、Transplant Proc 2018, 2016、Artif Organs. 2017, 2017、Front Immunol. 2016、Transpl Int. 2016、Cytokine. 2016).
Free Research Field	移植外科、移植免疫、急性血液浄化、バイオマーカー
Academic Significance and Societal Importance of the Research Achievements	本研究課題はこれまでの治療対象であったT cell主体の治療に加え、抗原提示細胞の１つである樹状細胞への変遷を予期させる革新的な研究成果となった。移植臓器の提供が少ない環境下で、安全に移植医療を提供をし得たことは十分な成果であり、同時に新たな治療戦略の可能性を示唆させる結果に繋がったのは、今後の移植医療における更なる可能性を予測させるものある。