Potency of recruited CD206+cells into recurrent oral cancer as a biomarker and treatment target

2019 Fiscal Year Final Research Report

• Project/Area Number: 17H04408
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: Kioi Mitomu 横浜市立大学, 医学部, 准教授 (30545059)
• Co-Investigator(Kenkyū-buntansha): 谷口 英樹 横浜市立大学, 医学研究科, 教授 (70292555) ; 藤内 祝 横浜市立大学, 医学研究科, 教授 (50172127)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: バイオマーカー

Outline of Final Research Achievements

In the present study, we investigated the potency of recruited CD206+cells into recurrent oral cancer as a biomarker. In a xenograft mouse model, local irradiation caused vascular damage and hypoxia in the tumor and increased infiltration of CD11b+ myeloid cells. These infiltrating cells showed characteristics of M2 macrophages (M2Mφs) and are associated with the promotion of vascularization. M2Mφs promoted tumor progression in recurrence after irradiation. In addition, we found that CD11b+ myeloid cells, as well as CD206+ M2Mφs, are increased during recurrence after radiotherapy in human OSCC specimens. We also found that monocytes were increased during the initial parts of the treatment in recurrent cases of oral cancer patients. Our findings indicate that CD11b+ cells has the potency of prognostic biomarker in oral cancer.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

口腔癌治療において局所再発は頸部リンパ節転移と並んで予後を著しく低下させることから、その克服が喫緊の重要な課題である。そのため、再発の早期発見は非常に重要であり、予後を予測させるマーカーの開発は生存率の向上など重要な社会的意義があると言える。また本研究にて予後予測マーカーが確立されることにより、他領域のがんのバイオマーカー発明にもつながり、学術的意義も含まれている。