バングラデシュにおけるポスト・カラ・アザール皮膚リーシュマニア症新規診断法の検証

2020 Fiscal Year Annual Research Report

• Project/Area Number: 17H04649
• Research Institution: Oita University
• Principal Investigator: 小林 隆志 大分大学, 医学部, 教授 (30380520)
• Co-Investigator(Kenkyū-buntansha): 濱野 真二郎 長崎大学, 熱帯医学研究所, 教授 (70294915)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: PKDL / バングラデシュ / 診断技術 / 節足動物媒介感染症 / チクングニア熱 / ジカ熱

Outline of Annual Research Achievements

本研究は、バングラデシュにおける節足動物媒介感染症の予防法・治療法・診断法の開発を目的とする。具体的には、バングラデシュにおいて、①内臓型リーシュマニア症患者のPKDL発症の原因となるリスクファクターの集積と解析を行い、②新規迅速診断キット（Dry LAMP）の現地での有用性を検証する。また、③チクングニア熱の新規迅速診断キットも開発しその有用性を検証する。さらに、④ジカ熱の増悪化因子の探求を行う。
最終年度に、新型コロナウイルス（COVID-19）の世界的パンデミックによって海外渡航が制限されたため、止むを得ず研究期間を延長させていただいた。2022年度までに、チクングニア熱に対するCHIKV LAMPの感度と特異性に関する実験室レベルのデータを追加した。４種類のチクングニアウイルス（CHIKV）株SL11131、SL10571、BaH306およびS27は、全て200PFUで検出可能であったが、CHIKV以外の節足動物媒介ウイルスとして使用したジカウイルス、デングウイルス（serotype 4）、日本脳炎ウイルスおよびロスリバーウイルスには反応しないことが確認された。また、感度に関しても、これまでの肉眼による蛍光の確認に加え、リアルタイムPCR装置で蛍光強度を検出する方法で、より定量性のある評価系を確立できた。これらの結果を学術論文にまとめ国際誌に成果を発表することができた。
一方、ジカ熱の増悪化因子の研究では、ウイルスのエンベロープタンパク質のN末端側近傍に細胞侵入能を規定する重要なアミノ酸が存在することを明らかにした。また、マウスにジカウイルスが感染すると自己免疫疾患の一つとして知られる多発性硬化症の病態が悪化することを見出した。この原因を遺伝子改変マウスを用いて解析し、研究成果を国際誌に投稿するための準備を進めている。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] CCL20/CCR6 chemokine signaling is not essential for pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis (2023)
  • Author(s): Sachi Nozomi、Kamiyama Naganori、Saechue Benjawan、Ozaka Sotaro、Dewayani Astri、Ariki Shimpei、Chalalai Thanyakorn、Soga Yasuhiro、Fukuda Chiaki、Kagoshima Yomei、Ekronarongchai Supanuch、Kobayashi Takashi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 641 Pages: 123～131
  • DOI: 10.1016/j.bbrc.2022.11.088
  • Peer Reviewed
• [Journal Article] GM-CSF-producing CCR2+CCR6+ Th17 cells are pathogenic in dextran sodium sulfate-induced colitis model in mice (2023)
  • Author(s): Ariki Shimpei、Ozaka Sotaro、Sachi Nozomi、Chalalai Thanyakorn、Soga Yasuhiro、Fukuda Chiaki、Kagoshima Yomei、Ekronarongchai Supanuch、Mizukami Kazuhiro、Kamiyama Naganori、Murakami Kazunari、Kobayashi Takashi
  • Journal Title: Genes to Cells Volume: 28 Pages: 267～276
  • DOI: 10.1111/gtc.13008
  • Peer Reviewed
• [Journal Article] Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor (2023)
  • Author(s): Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M.
  • Journal Title: Cancer Science Volume: 114 Pages: 2189～2202
  • DOI: 10.1111/cas.15735
  • Peer Reviewed / Open Access
• [Journal Article] Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression (2023)
  • Author(s): Hashizaki Emi、Sasai Miwa、Okuzaki Daisuke、Nishi Tsubasa、Kobayashi Takashi、Iwanaga Shiroh、Yamamoto Masahiro
  • Journal Title: mBio Volume: 14 Pages: e0325622
  • DOI: 10.1128/mbio.03256-22
  • Peer Reviewed / Open Access
• [Journal Article] TRAF6 signaling pathway in T cells regulates anti-tumor immunity through the activation of tumor specific Th9 cells and CTLs (2022)
  • Author(s): Dewayani Astri、Kamiyama Naganori、Sachi Nozomi、Ozaka Sotaro、Saechue Benjawan、Ariki Shimpei、Goto Mizuki、Chalalai Thanyakorn、Soga Yasuhiro、Fukuda Chiaki、Kagoshima Yomei、Maekawa Yoichi、Kobayashi Takashi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 613 Pages: 26～33
  • DOI: 10.1016/j.bbrc.2022.04.125
  • Peer Reviewed
• [Journal Article] Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation (2022)
  • Author(s): Ozaki T, Kamiyama N, Saechue B, Soga Y, Gotoh R, Nakayama T, Fukuda C, Dewayani A, Chalalai T, Ariki S, Ozaka S, Sonoda A, Hirose H, Gendo Y, Noguchi K, Sachi N, Hidano S, Maeshima K, Gotoh K, Masaki T, Ishii K, Osada Y, Shibata H, Kobayashi T.
  • Journal Title: Genes to Cells Volume: 27 Pages: 493～504
  • DOI: 10.1111/gtc.12944
  • Peer Reviewed
• [Journal Article] Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways (2022)
  • Author(s): Takada Ichiro、Hidano Shinya、Takahashi Sayuri、Yanaka Kaori、Ogawa Hidesato、Tsuchiya Megumi、Yokoyama Atsushi、Sato Shingo、Ochi Hiroki、Nakagawa Tohru、Kobayashi Takashi、Nakagawa Shinichi、Makishima Makoto
  • Journal Title: Journal of Biological Chemistry Volume: 298 Pages: 102342～102342
  • DOI: 10.1016/j.jbc.2022.102342
  • Peer Reviewed
• [Journal Article] Saireito, a Japanese herbal medicine, alleviates leaky gut associated with antibiotic-induced dysbiosis in mice (2022)
  • Author(s): Ozaka S, Sonoda A, Ariki S, Minata M, Kamiyama N, Hidano S, Sachi N, Ito K, Kudo Y, Dewayani A, Chalalai T, Ozaki T, Soga Y, Fukuda C, Mizukami K, Ishizawa S, Nishiyama M, Fujitsuka N, Mogami S, Kubota K, Murakami K, Kobayashi T.
  • Journal Title: PLOS ONE Volume: 17 Pages: e0269698
  • DOI: 10.1371/journal.pone.0269698
  • Peer Reviewed / Open Access
• [Journal Article] COVID-19 vaccination and liver disease (2022)
  • Author(s): Ozaka Sotaro、Kobayashi Takashi、Mizukami Kazuhiro、Murakami Kazunari
  • Journal Title: World Journal of Gastroenterology Volume: 28 Pages: 6791～6810
  • DOI: 10.3748/wjg.v28.i48.6791
  • Peer Reviewed / Open Access
• [Journal Article] Acute Cholecystitis Associated with Eosinophilic Granulomatosis with Polyangiitis that Responded to Glucocorticoid Therapy (2022)
  • Author(s): Ozaka Sotaro、Kodera Takamoto、Tsutsumi Koshiro、Fukuda Masahide、Iwao Masao、Hirashita Yuka、Takahashi Haruhiko、Fukuda Kensuke、Okamoto Kazuhisa、Arakawa Mie、Ogawa Ryo、Endo Mizuki、Mizukami Kazuhiro、Okimoto Tadayoshi、Kamiyama Naganori、Kodama Masaaki、Kobayashi Takashi、Murakami Kazunari
  • Journal Title: Internal Medicine Volume: Online ahead of print. Pages: -
  • DOI: 10.2169/internalmedicine.0437-22
  • Peer Reviewed
• [Journal Article] Acute pancreatitis soon after COVID-19 vaccination (2022)
  • Author(s): Ozaka Sotaro、Kodera Takamoto、Ariki Shimpei、Kobayashi Takashi、Murakami Kazunari
  • Journal Title: Medicine Volume: 101 Pages: e28471～e28471
  • DOI: 10.1097/MD.0000000000028471
  • Peer Reviewed / Open Access
• [Journal Article] Comment on “A case of acute necrotising pancreatitis following the second dose of Pfizer‐BioNTech COVID‐19 mRNA vaccine” (2022)
  • Author(s): Ozaka Sotaro、Kobayashi Takashi、Murakami Kazunari
  • Journal Title: British Journal of Clinical Pharmacology Volume: 88 Pages: 2449～2449
  • DOI: 10.1111/bcp.15159
  • Peer Reviewed / Open Access
• [Journal Article] Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier (2021)
  • Author(s): Ozaka S, Sonoda A, Ariki S, Kamiyama N, Hidano S, Sachi N, Ito K, Kudo Y, Minata M, Saechue B, Dewayani A, Chalalai T, Soga Y, Takahashi Y, Fukuda C, Mizukami K, Okumura R, Kayama H, Murakami K, Takeda K, Kobayashi T.
  • Journal Title: Genes to Cells Volume: 26 Pages: 807～822
  • DOI: 10.1111/gtc.12888
  • Peer Reviewed
• [Journal Article] Analysis of the Prevalence and Species of Anisakis nematode in Sekisaba, Scomber japonicus Caught in Coastal Waters off Saganoseki, Oita in Japan (2021)
  • Author(s): Hidano Shinya、Mizukami Kazuhiro、Yahiro Takaaki、Shirakami Kohei、Ito Hideyuki、Ozaka Sotaro、Ariki Shimpei、Saechue Benjawan、Dewayani Astri、Chalalai Thanyakorn、Soga Yasuhiro、Goto Mizuki、Sonoda Akira、Ozaki Takashi、Sachi Nozomi、Kamiyama Naganori、Nishizono Akira、Murakami Kazunari、Kobayashi Takashi
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 74 Pages: 387～391
  • DOI: 10.7883/yoken.JJID.2020.859
  • Peer Reviewed
• [Journal Article] Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential (2021)
  • Author(s): Kurogi Shusaku、Hijiya Naoki、Hidano Shinya、Sato Seiya、Uchida Tomohisa、Tsukamoto Yoshiyuki、Nakada Chisato、Yada Kazuhiro、Hirashita Teijiro、Inomata Masafumi、Murakami Kazunari、Takahashi Naohiko、Kobayashi Takashi、Moriyama Masatsugu
  • Journal Title: Pathobiology Volume: 88 Pages: 374～382
  • DOI: 10.1159/000514593
  • Peer Reviewed / Open Access
• [Journal Article] Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10 (2021)
  • Author(s): Morisaki Ikuko、Shiraishi Hiroshi、Fujinami Hiroyuki、Shimizu Nobuyuki、Hikida Takatoshi、Arai Yuji、Kobayashi Takashi、Hanada Reiko、Penninger Josef M.、Fujiki Minoru、Hanada Toshikatsu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 570 Pages: 60～66
  • DOI: 10.1016/j.bbrc.2021.07.036
  • Peer Reviewed
• [Journal Article] Development of a portable reverse transcription loop‐mediated isothermal amplification system to detect the E1 region of Chikungunya virus in a cost‐effective manner (2020)
  • Author(s): Saechue B, Kamiyama N, Wang Y, Fukuda C, Watanabe K, Soga Y, Goto M, Dewayani A, Ariki S, Hirose H, Ozaka S, Sachi N, Hidano S, Faisal K, Chowdhury R, Anik Ashfaq Khan M, Hossain F, Ghosh P, Shirin T, Mondal D, Murakami K, Kobayashi T.
  • Journal Title: Genes to Cells Volume: 25 Pages: 615～625
  • DOI: 10.1111/gtc.12797
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells (2020)
  • Author(s): Ratsada Praphasawat、Hijiya Naoki、Hidano Shinya、Tsukamoto Yoshiyuki、Nakada Chisato、Uchida Tomohisa、Kobayashi Takashi、Moriyama Masatsugu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 528 Pages: 586～593
  • DOI: 10.1016/j.bbrc.2020.05.140
  • Peer Reviewed
• [Journal Article] The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti (2020)
  • Author(s): Runtuwene Lucky R.、Kawashima Shuichi、Pijoh Victor D.、Tuda Josef S. B.、Hayashida Kyoko、Yamagishi Junya、Sugimoto Chihiro、Nishiyama Shoko、Sasaki Michihito、Orba Yasuko、Sawa Hirofumi、Takasaki Tomohiko、James Anthony A.、Kobayashi Takashi、Eshita Yuki
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Pages: 7520～7520
  • DOI: 10.3390/ijms21207520
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma (2020)
  • Author(s): Tada Kazuhiro、Ohta Masayuki、Hidano Shinya、Watanabe Kiminori、Hirashita Teijiro、Oshima Yusuke、Fujnaga Atsuro、Nakanuma Hiroaki、Masuda Takashi、Endo Yuichi、Takeuchi Yu、Iwashita Yukio、Kobayashi Takashi、Inomata Masafumi
  • Journal Title: Surgery Today Volume: 50 Pages: 767～777
  • DOI: 10.1007/s00595-019-01953-z
  • Peer Reviewed / Open Access
• [Presentation] Functional analysis of chemokine receptor CCR2 in a murine congenital toxoplasmosis model (2023)
  • Author(s): Naganori Kamiyama, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Masahiro Yamamoto, Takashi Kobayashi
  • Organizer: 第15回寄生虫感染免疫研究会
• [Presentation] Zika virus induces pathogenic T cell-attracting chemokines in the central nervous system and exacerbates experimental autoimmune encephalomyelitis (2022)
  • Author(s): Naganori Kamiyama, Thanyakorn Chalalai, Sotaro Ozaka, Shimpei Ariki, Yomei Kagoshima, Nozomi Sachi, Takashi Kobayashi
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] ケモカイン受容体 CCR2 のトキソプラズマ垂直感染に対する機能 (2022)
  • Author(s): 神山 長慶, THANYAKORN CHALALAI, 佐知 望美, 小坂 聡太郎, 有木 晋平, 曽我 泰裕, 鹿子嶋 洋明, SUPANUCH EKRONARONGCHAI, 小林 隆 志
  • Organizer: 第74回 日本寄生虫学会 南日本支部大会
• [Presentation] Physiological function of chemokine CCL20 and its receptor CCR6 in multiple sclerosis in mice (2022)
  • Author(s): Nozomi Sachi, Naganori Kamiyama, Sotaro Ozaka, Shimpei Ariki, Thanyakorn Chalalai, Yomei Kagoshima, Takashi Kobayashi
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] Secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier (2022)
  • Author(s): Sotaro Ozaka, Shimpei Ariki, Yomei Kagoshima, Naganori Kamiyama, Nozomi Sachi, Thanyakorn Chalalai, Astri Dewayani, Takashi Kobayashi
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] Physiological relevance of TRAF6 signaling in dendritic cells in controlling C. rodentium infection (2022)
  • Author(s): Thanyakorn Chalalai, Naganori Kamiyama, Shimpei Ariki, Sotaro Ozaka, Nozomi Sachi, Yomei Kagoshima, Ryu Okumura, Kiyoshi Takeda, Takashi Kobayashi
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] Identification of pathogenic Th17 cells in gastrointestinal tract using chemokine receptor deficient mice (2022)
  • Author(s): Shimpei Ariki, Sotaro Ozaka, Nozomi Sachi, Yomei Kagoshima, Thanyakorn Chalalai, Naganori Kamiyama, Takashi Kobayashi
  • Organizer: 第51回日本免疫学会学術集会
• [Presentation] Secretory leukocyte protease inhibitor ameliorates experimental colitis by protecting the intestinal epithelial barrier (2022)
  • Author(s): Sotaro Ozaka, Shimpei Ariki, Naganori Kamiyama, Yomei Kagoshima, Nozomi Sachi, Thanyakorn Chalalai, Yasuhiro Soga, Kazuhiro Mizukami, Kazunari Murakami, Takashi Kobayashi
  • Organizer: 第12回 癌・炎症と抗酸化研究会
• [Presentation] Zika virus induces Th17 cell-attracting chemokines in the central nervous system and exacerbates neurological disorders (2021)
  • Author(s): Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Chalalai Thanyakorn, Sotaro Ozaka, Shimpei Ariki, Chiaki Fukuda, Yasuhiro Soga, Mizuki Minata, Nozomi Sachi, Shinya Hidano, Takashi Kobayashi
  • Organizer: 学会等名 第44回日本分子生物学会年会
• [Presentation] Zika virus induces Th17 cell-attracting chemokines in the central nervous system and exacerbates experimental autoimmune encephalomyelitis (2021)
  • Author(s): Naganori Kamiyama, Benjawan Saechue, Astri Dewayan, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Sotaro Ozaka, Shimpei Ariki, Nozomi Sachi, Shinya Hidano, Takashi Kobayashi
  • Organizer: 第14回寄生虫感染免疫研究会
• [Presentation] 樹状細胞におけるTRAF6シグナルがCitrobacter rodentium感染性腸炎に与える役割. (2021)
  • Author(s): 望月晶子, Thanyakorn chalalai1, 伊藤加奈子, 有木 晋平, 小坂聡太郎, 佐知望美, 神山長慶, 小林隆志.
  • Organizer: 第11回 癌・炎症と抗酸化研究会(CIA研究会).
• [Presentation] 柴苓湯はマウスにおいて抗菌薬によるdysbiosisに起因するLeaky gutを軽減する. (2021)
  • Author(s): 小坂聡太郎, 有木晋平, 皆田美月, 神山長慶，佐知望美，Benjawan Saechue，Astri Dewayani, Thanyakorn Chalalai, 曽我泰裕, 福田千 瑛, 水上一弘, 村上和成, 小林隆志.
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 大建中湯のSLPI発現増強を介した腸管保護作用の解析. (2021)
  • Author(s): 皆田美月, 小坂聡太郎, 有木晋平, 神山長慶, 佐知望美, Benjawan Saechue, Astri Dewayani, Thanyakorn Chalalai, 曽我泰裕, 福田千 瑛, 水上一弘, 村上和成, 小林隆志.
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] Verification of T cell inhibitory effect of lipid mediator Oleylethanolamide (2021)
  • Author(s): Yasuhiro Soga, Naganori Kamiyama, Takashi Ozaki, Benjawan Saechue, Astri Dewayani, Nozomi Sachi, Sotaro Ozaka, Shinpei Ariki, Thanyakorn Chalalai, Chiaki Fukuda, Takashi Kobayash
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] "Identification of a responsible amino acid in prME protein for cell entry of Zika virus using single-round infectious particles (SRIPs)" (2021)
  • Author(s): Chiaki Fukuda, Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Chalalai Thanyakorn, Sotaro Ozaka, Shinpei Ariki, Yasuhiro Soga, Mizuki Minata, Nozomi Sachi, Shinya Hidano, Ryosuke Suzuki,Takashi Kobayashi
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] T細胞特異的TRAF6欠損マウスを用いた腸管におけるnon-pathogenic Th17細胞に関する研究 (2021)
  • Author(s): 有木晋平, 小坂聡太郎, 神山長慶, Benjawan Saechue, Astri Dewayani, Thanyakorn Chalalai, 佐知望美, 曽我泰裕, 福田千瑛, 水上一 弘, 村上和成, 小林隆志
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] TRAF6 regulates Th9 cells and cytotoxic T lymphocytes in tumor immunity (2021)
  • Author(s): Astri Dewayani, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Benjawan Saechue, Yasuhiro Soga, Thanyakorn Chalalai, Chiaki Fukuda, Takashi Kobayashi
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] CCL20欠損マウスを用いた多発性硬化症の発症におけるCCL20の機能解析 Analysis of the role of CCL20 in the development of multiple sclerosis using CCL20-deficient mice (2021)
  • Author(s): Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Takashi Kobayashi
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] C.rodentium感染における樹状細胞におけるTRAF6シグナルの役割 (2021)
  • Author(s): Thanyakorn Chalala, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Benjawan Saechue, Yasuhiro Soga, Astri Dewayani, Chiaki Fukuda, Takashi Kobayashi
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] TRAF6 promotes the migration of Th17 cells into the CNS by regulating CCR6 expression in experimental autoimmune encephalomyelitis mice (2020)
  • Author(s): Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Chalalai Thanyakorn, Sotaro Ozaka, Shinpei Ariki, Yasuhiro Soga, Mizuki Goto, Nozomi Sachi, Shinya Hidano, Takashi Kobayashi
  • Organizer: 第43回日本分子生物学会年会
• [Presentation] TRAF6 Signaling in Th9 cells Regulates Anti-Tumor Immune Response (2020)
  • Author(s): Astri Dewayani, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Benjawan Saechue, Mizuki Goto, Yasuhiro Soga, Thanyakorn Chalalai, Takashi Kobayashi
  • Organizer: 第43回日本分子生物学会年会