2017 Fiscal Year Annual Research Report
Development of novel graphene nanopore sensor for DNA sequencing
| Project/Area Number |
17H04907
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| Research Institution | Kyushu University |
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Principal Investigator |
Wang Haidong 九州大学, 工学研究院, 助教 (30729405)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | graphene / MEMS sensor / thermal rectification / nanowire |
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| Outline of Annual Research Achievements |
The research was carried out smoothly in 2017 and we have made several important achievements with the kind support from JSPS KAKENHI Grant-in-Aid for Young Scientists A. The main achievements are listed as below:
1. We have successfully fabricated graphene thermal rectification sensor for the first time in the world. It is a solid proof for our advanced nano-fabrication method and skill in making functional suspended graphene electronic devices. The fabrication processes of thermal rectification sensor and DNA sensor proposed in current project are the same. This work confirms the feasibility and ultra-high sensitivity of suspended monolayer graphene device, making a firm foundation for our future work. The result was published in Nature Communications.
2. We have successfully fabricated a single CdS nanowire electronic device with double MEMS sensors. The purpose of making single nanowire device was to prove the feasibility of our skill of nano-manipulation under SEM. Later the same equipment and method will be used to manipulate monolayer graphene and drill nanopores for DNA sensing. The result was published in RSC Advances.
3. We purchased a micro-bonding machine and confirmed its good performance in connecting micro-wires to the micro-electrodes. This technique is important for making the electrical circuit with graphene sensor connected in series. The high-precision oscilloscope can be used to capture transient current signals and analyze the DNA transportation through the nanopore.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The current project goes smoothly as expected. We have successfully made different kinds of suspended graphene sensors and published two high impact SCI journal papers. The feasibility of our new method was well confirmed in the experiment.
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| Strategy for Future Research Activity |
The most important part of our project is to drill a sub-10 nm nanopore in monolayer graphene. It is quite challenging since the graphene can be easily ruptured by high energy ion beam or electron beam. Also the precision control of nanopore size is very important for guaranteeing the final measurement accuracy of the graphene DNA sensor. We plan to develop a new method of using focused ion beam under SEM to drill nanopore in graphene, instead of using conventional high-cost TEM equipment. After that, the DNA molecule transportation through the single nanopore will be tested in the experiment.
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