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2020 Fiscal Year Final Research Report

Study of Drug Resistance in Cancer Cells to Develop Molecular Target Drugs

Research Project

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Project/Area Number 17H05056
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Satow Reiko  東京薬科大学, 生命科学部, 講師 (90469966)

Project Period (FY) 2017-04-01 – 2021-03-31
Keywordsがん / 薬剤耐性
Outline of Final Research Achievements

"Drug resistance" is a major problem that hinders the remission of cancer, and it is necessary to develop a therapeutic method that overcomes drug resistance. So far, the principal investigator has identified a protein that is highly expressed in many types of cancer, and promotes the survival and drug resistance of various cancers. In this research project, we screened for small molecule compounds and found multiple compounds that inhibit the function of this factor. We also identified several proteins that bind to and control this factor.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究課題において、がん特異的に高発現し様々な癌の生存や薬剤耐性を亢進させるタンパク質を阻害する低分子化合物を見出した。この低分子化合物は、メラノーマや薬剤耐性メラノーマに細胞死を誘導したが、正常ヒトメラノサイトや正常ヒトケラチノサイトには細胞死を誘導しなかった。これらのことから、同定した低分子化合物がメラノーマや薬剤耐性メラノーマに有効であると考えられる。また、このタンパク質の制御機構を明らかにすることでさらなる治療薬の開発につながる。

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Published: 2022-01-27  

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