ヒト生殖細胞発生機構の解明とその試験管内再構成

Products Report

• Project/Area Number: 17H06098
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Saitou Mitinori 京都大学, 高等研究院, 教授 (80373306)
• Co-Investigator(Kenkyū-buntansha): 築山 智之 滋賀医科大学, 動物生命科学研究センター, 特任准教授 (60612132) ; 中村 紳一朗 滋賀医科大学, 動物生命科学研究センター, 准教授 (50307980)
• Project Period (FY): 2017-04-25 – 2022-03-31

Research Products

• [Journal Article] In vitro reconstitution of epigenetic reprogramming in the human germ line (2024)
  • Author(s): Yusuke Murase, Ryuta Yokogawa, Yukihiro Yabuta, Masahiro Nagano, Yoshitaka Katou, Manami Mizuyama, Ayaka Kitamura, Pimpitcha Puangsricharoen, Chika Yamashiro, Bo Hu, Ken Mizuta, Taro Tsujimura, Takuya Yamamoto, Kosuke Ogata, Yasushi Ishihama, Mitinori Saitou
  • Journal Title: Nature Volume: 631 Pages: 170-178
  • DOI: 10.1038/s41586-024-07526-6
  • Peer Reviewed / Open Access
• [Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys (2023)
  • Author(s): Sayuri Gyobu-Motani, Yukihiro Yabuta, Ken Mizuta, Yoshitaka Katou, Ikuhiro Okamoto, Masanori Kawasaki, Ayaka Kitamura, Tomoyuki Tsukiyama, Chizuru Iwatani, Hideaki Tsuchiya, Taro Tsujimura, Takuya Yamamoto, Tomonori Nakamura, Mitinori Saitou
  • Journal Title: The EMBO Journal Volume: 42 Pages: e112962
  • DOI: 10.15252/embj.2022112962
  • Peer Reviewed
• [Journal Article] Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stemcells (2022)
  • Author(s): Yukiko Ishikura, Hiroshi Ohta, Masahiro Nagano, Mitinori Saitou
  • Journal Title: STAR Protocols Volume: 3 Pages: 101544
  • DOI: 10.1016/j.xpro.2022.101544
  • Peer Reviewed / Open Access
• [Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development (2022)
  • Author(s): Masahiro Nagano ; Bo Hu ; Shihori Yokobayashi ; Akitoshi Yamamura ; Fumiya Umemura ; Mariel Coradin ; Hiroshi Ohta ; Yukihiro Yabuta ; Yukiko Ishikura ; Ikuhiro Okamoto ; Hiroki Ikeda ; Naofumi Kawahira ; Yoshiaki Nosaka ; Sakura Shimizu ; Yoji Kojima ; Ken Mizuta ; Tomoko Kasahara ; Yusuke Imoto ; Killian Meehan ; Roman Stocsits ; Gordana Wutz ; Yasuaki Hiraoka ; Yasuhiro Murakawa ; Takuya Yamamoto ; Kikue Tachibana ; Jan -Michel Peters ; Leonid A Mirny ; Benjamin A Garcia ; Jacek Majewski ; Mitinori Saitou
  • Journal Title: The EMBO Journal Volume: 41 Pages: e110600
  • DOI: 10.15252/embj.2022110600
  • Peer Reviewed / Int'l Joint Research
• [Patent(Industrial Property Rights)] 卵原細胞又は前精原細胞の製造方法 (2023)
  • Inventor(s): 斎藤通紀、村瀬佑介、横川隆太
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2023-133928