Mechanotransduction mechanism that controls site-specific tissue response in periodontal ligament

2018 Fiscal Year Final Research Report

• Project/Area Number: 17H06698
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Niigata University
• Principal Investigator: Kitami Kohei 新潟大学, 医歯学総合病院, 医員 (20804579)
• Project Period (FY): 2017-08-25 – 2019-03-31
• Keywords: プライマリーシリア / 歯根膜

Outline of Final Research Achievements

Periodontal ligament is extremely sensitive to mechanical stimuli, that enables orthodontic tooth movement. It remains elusive how mechanical stimuli are perceived and controlling tissue modification. In this study, we analyzed the distribution and the mechano-response of primary cilia, which is expected to function as a mechanoreceptor in periodontal ligament, in response to orthodontic tooth movement. Primary cilia was present in periodontal ligament, and preferential localization at the cementum-side of periodontal ligament was observed. The rate of cilia-positive cells was altered after orthodontic tooth movement.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

本研究は、機械的刺激受容体としての機能が期待されるプライマリーシリアの歯根膜組織中の局在特性に着目し、その作用機序を明らかにしようとするものである。プライマリーシリアによる機械的刺激に対する細胞応答メカニズムの解明は、あらゆる機械的刺激にさらされる生体機能の理解に向けたメカノバイオロジーの観点から、疾患の発生、治癒、再生を含めた今後の医歯薬学領域における研究の発展に大きく寄与することが期待される。