Development of novel pharmacotherapy by thrombomodulin-alfa for severe infection and DIC

2018 Fiscal Year Final Research Report

• Project/Area Number: 17H06764
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Suzuka University of Medical Science (2018); Mie University (2017)
• Principal Investigator: Enokiya Tomoyuki 鈴鹿医療科学大学, 薬学部, 准教授 (60803260)
• Research Collaborator: Okuda Msahiro ; Imai Hiroshi ; Maruyama Kazuo
• Project Period (FY): 2017-08-25 – 2019-03-31
• Keywords: thrombomodulin-alfa / 播種性血管内凝固症候群

Outline of Final Research Achievements

The aim of study is to reveal pharmacological action mechanism of thrombomodulin alfa (TMα) and lead to development of novel pharmacotherapy for septic Disseminated Intravascular Coagulation (DIC). We analyzed plasma of 10 DIC patients participated in this study. 113 proteins were identified. Functional associations among 39 proteins were identified. Moreover, 23 proteins are associated with progression to sever sepsis or DIC. We plan to validate interaction and functional association between TMα and their identified proteins in vivo and in vitro.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

敗血症性DICは予後不良であり、死亡率が高い。そのため、治療法の改善が求められている。TMαはDICに対して唯一生存期間の延長が認められた薬物であるが、血液凝固を抑制するため出血傾向が高くなる。本研究で同定したTMαと相互作用しているタンパク質がどのようにTMαと機能的に関連しているかを明らかにすることで、血液凝固に影響しないDIC治療薬の標的分子を見出すことに繋がり、新規DIC治療薬の開発に発展すると考えられた。