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2018 Fiscal Year Final Research Report

Development of iPS cell-based functional working memory model in vitro

Research Project

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Project/Area Number 17H07358
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Yada Yuichiro  国立研究開発法人理化学研究所, バイオリソース研究センター, 特別研究員 (80805797)

Research Collaborator Inoue Haruhisa  
Imamura Keiko  
Project Period (FY) 2017-08-25 – 2019-03-31
Keywords多点電極アレイ / iPS細胞由来神経細胞 / 神経同期活動
Outline of Final Research Achievements

The aim of this project was developing a method to evaluate cellular working memory by electrical stimulation. We cultivated mouse/human iPSC (induced pluripotent stem cell) derived neurons on multi-electrode array, so that patterned stimulation can be added to the cell population. We investigated the suitable experimental conditions, including cultivation period, of the cells for the experiment.

Free Research Field

神経工学

Academic Significance and Societal Importance of the Research Achievements

iPS細胞を使用して培養皿上に神経疾患を再現し、有効な薬剤を探索するなどの創薬基盤として利用することに注目が集まっている。認知症などの神経「機能」の疾患モデルを評価する上では、遺伝子やタンパク質の発現、細胞死や形態変化に留まらず、培養皿上の神経集団機能を評価する方法の開発が有用と考えられる。本研究を礎として、電気刺激応答による機能評価手法の開発が期待される。

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Published: 2020-03-30  

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