2021 Fiscal Year Final Research Report
Natural selection driven structure building in a tunable DNA-only system
| Project/Area Number |
17K00399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Ochanomizu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Keywords | DNA Nanostructures / Molecular Robotics / Quality-Diversity / Robustness to failure |
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| Outline of Final Research Achievements |
In the present research, we proposed that relying on chemical reaction networks (CRNs) is a way to implement large DNA structures with a limited set of DNA strands, producing families of structures rather than a single target structure. Our goal was to implement a framework for the design and evaluation of sets of DNA strands capable of folding into rich families of structures. We used the framework we developed during this project to analyze three libraries of DNA strands with different features and analyzed the typical structures emerging from sets of strands based on those libraries.
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| Free Research Field |
分子ロボティクス
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| Academic Significance and Societal Importance of the Research Achievements |
最終的に構造体の設計者を支援する設計規則を示し、構造体の開発コストを削減することを目指す。特に、これらの結果から、ある程度の複雑性を持たせるには、一定数のドメインタイプが必要であると考えられる。また、フレームワークのコードをオープンソースプロジェクトとしてシェアした。
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