2017 Fiscal Year Research-status Report
Computer modeling of cardiac conduction system with nonlinear oscillators
| Project/Area Number |
17K00411
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| Research Institution | The University of Aizu |
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Principal Investigator |
Maxim・V Ryzhii 会津大学, コンピュータ理工学部, 准教授 (50254082)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | Heart model / ECG / HRV / cardiac / conduction system / nonlinear equation |
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| Outline of Annual Research Achievements |
We are working on the modification of our cardiac oscillator model to include dual atrioventricular node in a simple way. For this purpose we developed rather simple Matlab/Simulink model of cardiac conduction system which is able demonstrating various abnormal situations of cardiac electrical activity generating physiologically correct ECG signals. We also developed extended heterogeneous oscillator model of cardiac conduction system for generation of realistic 12 lead ECG waveforms, which includes artificial RR-tachogram with the specific statistics of heart rate, the frequency-domain characteristics of heart rate variability (HRV) produced by Mayer and respiratory sinus arrhythmia waves, normally distributed additive noise and a baseline wander that couple the respiratory frequency.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We faced some difficulty selecting particular type of nonlinear differential equations for sinoatrial (SA), atria-ventricular (AV) nodes and internodal pathway cells to achieve nodal reentry effect, keeping automaticity of SA and AV nodes and balancing input-output signal levels for different types of node equations. Despite of this, we have some preliminary results for different types of nonlinear differential equations used. We consider modified van der Pol, Leinart-transferred van der Pol and Aliev-model type nonlinear equations for the nodal and internodal cells.
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| Strategy for Future Research Activity |
We are going to extend the model to successfully simulate the nodal reentry process with relatively simple scheme with reduced number of elements (oscillators) coupled with pertinent delays between SN and AV nodes. We will test the model under the influence of external low-frequency modulated signals to investigate the appearance of reversible and irreversible blocks in cardiac electrical conduction system. Pertinent software in Matlab and Simulink environments will be developed.
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