Human exposure and disposition of naturally occuring brominated biphenols and anthropogenic persistent organohalogens

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K00574
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Daiichi University, College of Pharmaceutical Sciences
• Principal Investigator: Haraguchi Koichi 第一薬科大学, 薬学部, 教授 (00258500)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: 体内動態 / 臭素化合物 / 海藻 / 天然化合物

Outline of Final Research Achievements

The origin of naturally produced and persistent brominated biphenyls (OH-BDEs) was found to be marine alga (Sargassum sp.) from east Asia. These OH-BDEs were accumulated as methoxylated products in higher trophic organisms such as cetaceans, followed by fish. Human exposure to MeO-BDEs via diet may result in hepatic metabolism by CYP2B6 to OH-BDEs, of which 6-OH-BDE47 may be retained in blood of human.

Free Research Field

環境衛生

Academic Significance and Societal Importance of the Research Achievements

ヒトや海洋哺乳動物には残留性有機汚染物質(POPs)と同レベルで天然由来の臭素化ビフェノール類(OH-BDE)が広範囲で検出されている。本研究では、海藻由来のOH-BDEのメチル化体が、食物連鎖により魚介類やヒト食事に検出されること、またヒトに取り込まれたMeO-PBDEは容易に脱メチル化されやすいことを明らかにした。OH-BDEは、抗菌・抗酸化能や内分泌かく乱性を有すると考えられ、そのヒト影響研究の基礎資料となる。