Control of obesity and inflammatory bowel disease by polyunsaturated fatty acid adjusted diet

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K00856
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Dokkyo Medical University (2018-2019); Yamaguchi University (2017)
• Principal Investigator: Nobuko Tokuda 獨協医科大学, 医学部, 教授 (70227578)
• Co-Investigator(Kenkyū-buntansha): 大和田 祐二 東北大学, 医学系研究科, 教授 (20292211) ; 山本 由似 東北医科薬科大学, 医学部, 助教 (80635087)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脂肪酸 / 炎症 / 肥満 / FABP

Outline of Final Research Achievements

Intake of n-3 fatty acid deficient diet and deficiency of FABP7 (brain-type fatty acid binding protein), which has high affinity for n-3 fatty acids, may affect weight gain, peripheral immune cell number and differentiation. FABP7 deficiency suppressed food intake and obesity when a high-fat diet was consumed. FABP7 has also been shown to play a role in regulating inflammation and protecting cell death. Another polyunsaturated fatty acid regulator has also been shown to control the exacerbation of inflammatory bowel disease.

Free Research Field

解剖学・免疫学

Academic Significance and Societal Importance of the Research Achievements

多価不飽和脂肪酸が肥満や炎症に与える影響について、これまで栄養学的な知見によって確認されてきた事項を、動物モデルや細胞学的なデータから解析し、その機序の一旦を示すことができた。定常状態の解析結果については疾患の予防、炎症時の解析結果については疾患の機序の解明や新しい治療の開発に繋げることができると考えられる。