Research for signaling molecules that regulate mast cell-mediated allergic reactions

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K00907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: National Institute of Health Sciences
• Principal Investigator: Tamehiro Norimasa 国立医薬品食品衛生研究所, 生化学部, 協力研究員 (80597881)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: マスト細胞

Outline of Final Research Achievements

Our group has established a rat-derived mast cell line RS-ATL8 cells expressing human FceRI and developed the EXiLE for detecting antigen-specific IgE antibodies present in human serum. This system retains normally IgE signaling-induced degranulation responses and can be used in research for signal molecules in mast cell. In this study, we searched for molecules that regulate mast cell degranulation. With the library of food-derived compounds and 220 protein kinase agonists / antagonists classified by kinome, we found 21 compounds that regulate mast cell degranulation. Ontology analysis suggested the presence of the novel IgE signaling.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

食物アレルギーや花粉症をはじめとする、抗原によるマスト細胞の活性化により惹起されるアレルギー疾患は、科学的知見に基づく医療を受けることで症状のコントロールがおおむね可能となってきているが、全ての患者がその恩恵を受けているわけではないという現状が指摘されており、診療・管理ガイドラインにのっとった医療のさらなる普及が望まれている。