Elucidation of the relationship between intestinal microbiota, inflammatory immunity and leaky gut in major depressive disorder.

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K00908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nagoya Keizai University
• Principal Investigator: Aizawa Emiko 名古屋経済大学, 人間生活科学部管理栄養学科, 教授 (00639049)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 大うつ病 / 腸内細菌 / Leaky gut

Outline of Final Research Achievements

Subject were19 patients with Major depressive disorder and 50 healthy controls.
Fecal sample were analyzed using two-step polymerase chain reaction (PCR) and next-generation 16S rRNA gene sequencing. Intestinal permeability was evaluated using the lactulose / mannitol test.The abundance of several bacteria were found significant differences, although, there was no difference in intestinal permeability measured by Lactulose-Mannitol test between patients and controls.

Free Research Field

精神栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究成果によって、腸内細菌叢構成が健常者と大うつ病患者とでは異なることが分かった。このことにより、腸内細菌構成のアプローチが治療や予防に効果がある可能性を示すことが出来た。出生早期より腸内細菌構成が確定してくることから、出生前の腸内細菌を考慮した環境への配慮、食習慣との関係についても望ましい対応について追及していく必要がある。