Multimodal imaging of cancerous regions utilizing spectral X-ray CT and 7T-MRI

2019 Fiscal Year Annual Research Report

• Project/Area Number: 17K01424
• Research Institution: Toho University
• Principal Investigator: 渡邉 学 東邦大学, 医学部, 教授 (30297709)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: スペクトラルX線CT / トリプルエネルギーCT / CdTeアレー / ビームハードニングCT / 3次元イメージング / 7T-MRI / ブドウ糖 / ガドペント酸メグルミン

Outline of Annual Research Achievements

●スペクトラルⅩ線CT：　第一世代のトリプルエネルギーCTにおいて，画像再構成ピクセルサイズを0.1mmに設定し，空間分解能を0.2mmまで改善した。次いで，被写体でのビームハードニングを利用したエネルギー弁別CTを構築した。検出器の最大出力電圧を一定にし，トリプル増幅器で得られるプロジェクションデータから画像再構成を行った。実験では増幅率を高めることにより，平均フォトンエネルギーが増加することを確認した。さらに，アナログ増幅器1台とデジタル増幅器2台を用いたトリプルエネルギーCTも構築し，上述のアナログ3台の場合と同等の画質を得ることができた。
●スペクトラル3次元Ⅹ線CT：　CdTeアレーと0.1mmフォーカスⅩ線管を用い，コーンビームを使ったトリプルエネルギーCTを構築し，ファントムなどを撮影した。スレッショルドエネルギーは33と50keVで，1.5倍拡大撮影により0.08mm程度の空間分解能が得られ，3次元イメージングを実現した。
●ブドウ糖の癌造影効果：　ブドウ糖は癌に容易に吸収され，過剰な分は脂肪に変化する。大腿にVX2癌が生着したウサギにブドウ糖を静脈注射し，3日後に7T-MRIとT1強調撮影を用いて撮影した結果，癌部位のグレイ濃度が若干増加した。
●ガドペント酸メグルミン・ブドウ糖の癌造影効果：　ブドウ糖注射液に適量のガドペント酸メグルミンを加え，大腿にVX2癌が生着したウサギの耳から静脈注射した。次いで，7T-MRIとT1強調撮影を用いて癌部位における造影剤の陽性造影効果の時間変化を撮影し，90分以上，癌部位のグレイ濃度が増加した。

Research Products

• [Journal Article] Triple-sensitivity high-spatial-resolution X-ray computed tomography using a cadmium-telluride detector and its beam-hardening effect (2020)
  • Author(s): Yoshida, S., Sato, E., Oda, Y., Yoshioka, K., Moriyama, H., Watanabe, M.
  • Journal Title: Appl. Radiat. Isot. Volume: 159 Pages: 109089
  • DOI: 10.1016/j.apradiso.2020.109089.
  • Peer Reviewed
• [Journal Article] Near-infrared-ray computed tomography with 850-nm peak and high spatial resolutions in first living-body window (2019)
  • Author(s): Sato, E., Yoshida, A., Someya. T., Oda, Y., Yoshida, S., Yoshioka, K., Sato, Y., Moriyama, H., Watanabe, M.
  • Journal Title: Phys. Open Volume: 2 Pages: 100010
  • DOI: 10.1016/j.physo.2019.100010
  • Peer Reviewed / Open Access
• [Journal Article] Near-infrared-ray computed tomography with 850-nm peak and high spatial resolutions (2019)
  • Author(s): Sato, E., Yoshida, A., Someya. T., Yoshizawa, T., Morimoto, M., Mine, T., Oda, Y., Yoshida, S., Yoshioka, K., Sato, Y.
  • Journal Title: Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci. Volume: 54 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Measurement of penetrating photon spectra using a white power light-emitting diode (2019)
  • Author(s): Sato, E., Oda, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
  • Journal Title: Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci. Volume: 54 Pages: 9-12
  • Peer Reviewed
• [Journal Article] Investigation of low-dose energy-dispersive x-ray computed tomography utilizing beam hardening (2019)
  • Author(s): Yoshida, S., Sato, E., Oda, Y., Yoshioka, S., Ehara, S., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
  • Journal Title: Proc. SPIE Volume: 11114 Pages: 111141H-1-6
  • DOI: 10.1117/12.2529663
  • Int'l Joint Research
• [Journal Article] Intense nickel-K-photon irradiation from weakly-ionized linear plasma x-ray source with a reflector (2019)
  • Author(s): Sato, E., Sato, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Watanabe, M.
  • Journal Title: Proc. SPIE Volume: 11114 Pages: 111141E-1-6
  • DOI: 10.1117/12.2526546
  • Int'l Joint Research
• [Journal Article] Photon-counting x-ray computed tomography using a YAP(Ce)-PMT detector and beam hardening (2019)
  • Author(s): Watanabe, M., Sato, E., Yoshida, S., Yoshioka, K., Oda, Y., Moriyama, H., Hagiwara, O., Enomoto, T.
  • Journal Title: Proc. SPIE Volume: 11114 Pages: 111141D-1-6
  • DOI: 10.1117/12.2530767
  • Int'l Joint Research
• [Journal Article] Measurement of humanbody-window spectra using a white power light-emitting diode and its application to high-spatial-resolution computed tomography (2019)
  • Author(s): Moriyama, H., Sato, E., Oda, Y., Yoshida, S., Hagiwara, O., Enomoto, T., Watanabe, M.
  • Journal Title: Proc. SPIE Volume: 11073 Pages: 1107321-1-6
  • DOI: 10.1117/12.2527720
  • Int'l Joint Research
• [Journal Article] 850-nm near-infrared-ray computed tomography with high spatial resolutions (2019)
  • Author(s): Sato, E., Oda, Y., Sato, Y., Yoshida, S., Moriyama, H., Watanabe, M.
  • Journal Title: Proc. SPIE Volume: 11073 Pages: 110730N-1-6
  • DOI: 10.1117/12.2526543
  • Int'l Joint Research
• [Journal Article] Intense nickel-K-photon irradiation from weakly-ionized linear plasma x-ray source with a zinc reflector (2019)
  • Author(s): Sato, E., Oda, Y., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
  • Journal Title: Proc. SPIE Volume: 11051 Pages: 110510G-1-5
  • DOI: 10.1117/12.2526546
  • Int'l Joint Research
• [Journal Article] High-speed tripe-energy x-ray photoncounter using a room-temperaturecadmium-telluride detector and itsapplication to high-spatial-resolutionlow-dose computed tomography (2019)
  • Author(s): Watanabe, M., Sato, E., Oda, Y., Sato, Y, Yamaguchi S., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Kusachi, S.
  • Journal Title: Proc. SPIE Volume: 11051 Pages: 110510H-1-8
  • DOI: 10.1117/12.2323756
  • Int'l Joint Research
• [Journal Article] High-speed dual-energy x-ray photoncounter using a YAP(Ce)-photomultiplier detector and itsapplication to low-dose computedtomography (2019)
  • Author(s): Sato, Y., Sato, E., Oda, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
  • Journal Title: Proc. SPIE Volume: 11051 Pages: 110510I-1-9
  • DOI: 10.1117/12.2524632
  • Int'l Joint Research
• [Presentation] Investigation of low-dose energy-dispersive x-ray computed tomography utilizing beam hardening (2019)
  • Author(s): Yoshida, S., Sato, E., Oda, Y., Yoshioka, S., Ehara, S., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
  • Organizer: SPIE Optics+Photonics, San Diego
• [Presentation] Intense nickel-K-photon irradiation from weakly-ionized linear plasma x-ray source with a reflector (2019)
  • Author(s): Sato, E., Sato, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Watanabe, M.
  • Organizer: SPIE Optics+Photonics, San Diego
• [Presentation] Photon-counting x-ray computed tomography using a YAP(Ce)-PMT detector and beam hardening (2019)
  • Author(s): Watanabe, M., Sato, E., Yoshida, S., Yoshioka, K., Oda, Y., Moriyama, H., Hagiwara, O., Enomoto, T.
  • Organizer: SPIE Optics+Photonics, San Diego
• [Presentation] 850-nm near-infrared-ray computed tomography with high spatial resolutions (2019)
  • Author(s): Sato, E., Oda, Y., Sato, Y., Yoshida, S., Moriyama, H., Watanabe, M.
  • Organizer: European Conferences on Biomedical Optics, Munich.
• [Presentation] Measurement of human-body-window spectra using a white power light-emitting diode and its application to high-spatial-resolution computed tomography (2019)
  • Author(s): Moriyama, H., Sato, E., Oda, Y., Yoshida, S., Hagiwara, O., Enomoto, T., Watanabe, M.
  • Organizer: European Conferences on Biomedical Optics, Munich.