Elucidation of the mechanism of action of disease development associated with aging by a newly developed stimulation method and examination of its utilization development.

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K01484
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: Yamada Kouji 藤田医科大学, 保健学研究科, 教授 (60278306)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 骨密度 / 振動 / 振盪 / 骨形態計測 / マイオカイン

Outline of Final Research Achievements

We have newly created a combination stimulator that combines a vibration stimulator that activates aged cells during fracture healing and a shaking stimulator that cultivates a sense of balance to prevent falls. Ovariectomized mice with reduced bone density were prepared and subjected to combination stimulation for 30 minutes a day for 10 weeks. As a result, the osteoid width (O.Th), osteoid mass (OV/BV), and bone mineralization rate (MAR) were significantly higher in the stimulated group than in the unstimulated group, which was the target group (p<0.05). Moreover, in the expression analysis of BMP-2, IL-1β, IL-6, and MyoD in the lower limb zone, the value in the stimulated group was significantly higher than that in the unstimulated group (p<0.05). Since the bone mass (OV/BV) and bone mineralization rate (MAR) were high, it was suggested that this stimulus might promote bone formation.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

新規に振盪と振動のコンビネーション刺激装置を作製し、骨密度低下モデルマウスにて検証したところ、骨代謝が活発に行われることが示唆された。また、腰椎は骨粗鬆症が原因で骨折する好発部位の１つで体幹の深部にあり刺激をすることが困難である。その腰椎において開発した装置により一定の効果が得られたことは、予防医学として閉経前後女性を対象としたヒトへの装置開発、効果の検証により将来臨床応用できる知見が得られた。