Exercise increases neural stem cell number around the area of damage following rat traumatic brain injury

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K01486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kindai University
• Principal Investigator: Itoh Tatsuki 近畿大学, 農学部, 教授 (40330245)
• Co-Investigator(Kenkyū-buntansha): 井上 敬夫 近畿大学, 医学部, 助教 (00441006) ; 佐藤 隆夫 近畿大学, 大学病院, 教授 (70162443)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 脳外傷 / 運動 / 神経再生 / リハビリテーション

Outline of Final Research Achievements

From our current study, we propose that the exercise in the early following traumatic brain injury increases the number of nestin-positive cells-including NSCs- with the potential to differentiate into neurons and glia around the area damaged by TBI, and enhanced proliferation activity of neural stem cells (NSCs) around damaged area after traumatic brain injury(TBI). Therefore, the exercise therapy (rehabilitation) in the early phase following TBI is very important for recuperation of induced cerebral dysfunction following TBI.

Free Research Field

神経化学

Academic Significance and Societal Importance of the Research Achievements

脳外傷後早期から運動（リハビリテーション）をすることは脳損傷後における損傷部位での神経幹細胞の増殖能力を高め、神経再生を誘導し、神経再生治療に有効であり、早期からの運動が社会復帰を早める可能性が示された。