Effect of exercise training on beiging of hypertrophied white adipocytes in subcutaneous

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K01764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Asahikawa Medical College
• Principal Investigator: Ogasawara Junetsu 旭川医科大学, 医学部, 講師 (20415110)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: ベージュ脂肪細胞 / 肥大化白色脂肪細胞 / 運動トレーニング / 高脂肪食摂取

Outline of Final Research Achievements

Beige adipocytes are able to expend the energy through heat production as well as brown adipocytes. Therefore, transforming from white adipocyte to beige adipocytes are useful for establishing a new anti-obesity therapy. In this study, Wistar rats were divided into two groups; sedentary control (only high-fat diet intake) group and high-fat diet intake with exercise training group. Exercise training were significantly decreased in body weight, serum insulin and blood glucose compared with control group. Under these conditions, expression of beige adipocytes, which have multilocular form as well as brown adipocytes, were observed in subcutaneous adipose tissue. Levels of central molecules, which are related with formation of beige adipocytes, i.e. PPAR-gamma and PRDM-16, were significantly changed compared with control group. These results suggest that exercise training is beneficial for beiging of subcutaneous white adipocytes which are hypertrophied by high-fat diet intake.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

ベージュ脂肪細胞は、白色脂肪細胞が形質転換することによって形成され、一部の糖尿病治療薬の投与や運動トレーニングによって皮下白色脂肪組織に形成される。ベージュ脂肪細胞は褐色脂肪細胞と同様に熱産生を介してエネルギーを消費するため、エネルギー消費を行わない白色脂肪細胞のベージュ脂肪細胞化は抗肥満療法へと応用できる可能性がある。本研究の結果は、肥満により肥大化した皮下白色脂肪組織においても運動トレーニングはベージュ脂肪細胞を作り出すことができることを明らかにしており、運動療法としての運動トレーニングが従来通り有効であることや、肥満者にも適応できる可能性について学術的に証明した点に社会的な意義がある。