2019 Fiscal Year Final Research Report
Exploring catalytic functions of selenocysteine
| Project/Area Number |
17K05792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | セレン / セレノシステイン / 酵素モデル / ペプチド合成 / セレノインスリン / セレノグルタチオン / 環状ペプチド |
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| Outline of Final Research Achievements |
The aim of this research project was to explore the catalytic functions of selenocysteine. In this project, the following outcomes were obtained. An easy and efficient method to produce selenocysteine derivatives from natural amino acid serine was established. Using the obtained selenocysteine derivatives, novel catalytic organic transformation reactions were found, mimics of selenoenzymes were developed, a convenient synthetic method was established for selenoglutathione, a selenoinsulin analog was synthesized, and the synthesis of cyclic selenopeptides was achieved by application of intramolecular native chemical ligation.
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| Free Research Field |
生体関連化学
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| Academic Significance and Societal Importance of the Research Achievements |
セレノシステインは遺伝子情報によってタンパク質に直接組み込まれる第２１番目のアミノ酸である。セレノシステインを活性中心に含むセレン酵素は多数知られているが、これまでその反応メカニズムの詳細が酵素に近いアミノ酸モデルを用いて研究されたことはほとんどなかった。本研究では、セレノシステイン誘導体を用いた研究によって、その一端を明らかにすることができた。研究成果は創薬への応用が期待される。
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