2020 Fiscal Year Final Research Report

Development of catalysts for C-S coupling reactions in water

Research Project

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Project/Area Number	17K05814
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Inorganic chemistry
Research Institution	Osaka City University
Principal Investigator	Nishioka Takanori 大阪市立大学, 大学院理学研究科, 准教授 (10275240)
Project Period (FY)	2017-04-01 – 2021-03-31
Keywords	硫黄化合物 / 金属錯体 / 糖修飾配位子
Outline of Final Research Achievements	Investigation of new catalysts for coupling reactions in water, which is a safer solvent compared with toxic and/or flammable organic solvents, was performed. Sugar units were introduced into metal complex catalysts to enhance their water solubility. Palladium, nickel, and rhodium were used to synthesize metal complexes. The complexes worked as catalysts for carbon-carbon coupling reactions in water but not for carbon-sulfur coupling. Multinuclear complexes containing sulfide ligands were also synthesized. Electrochemical measurements of these complexes in the presence of alkyl halides suggested their potential of applications for coupling reactions.
Free Research Field	有機金属化学
Academic Significance and Societal Importance of the Research Achievements	有機化合物の合成に一般的に用いられる有機溶媒は毒性があるものや可燃性のものが多いため、代わりに水を用いることができれば作業環境や環境保全に役立つ。本研究では、水中での有機合成に用いることのできる触媒開発をめざし、金属錯体に水への溶解性が非常に高い糖を導入する合成法を確立した。また、合成した水溶性の金属錯体が、水中での炭素－炭素結合生成反応の触媒として有用であることを明らかにした。この研究成果は、薬品や化成品の製造における持続可能社会の確立に貢献するものである。