Control performance analysis of DNA regulator and design and application of DNA combination circuits

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K06500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Control engineering/System engineering
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: Nakakuki Takashi 九州工業大学, 大学院情報工学研究院, 教授 (30435664)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: DNAレギュレータ / 生体分子反応系 / 非線形システム / 制御理論 / 特異摂動理論 / XOR回路 / オン・オフスイッチ回路 / DNAコンピューティング

Outline of Final Research Achievements

In this study, a new concept of “finite-time regulation property” has been defined for the regulation problem of DNA regulator. By applying the proposed coordinate transformation along with the properties of DNA strand displacement mechanism to the DNA regulator system, the non-standard singular perturbation theory has been established, which is expected to apply to various kinds of DNA regulators. In addition, a new XOR circuit that does not use the dual-rail method has been successfully designed, where a novel method for determining DNA base sequences by using mismatch base-pairs has been proposed. Furthermore, an on/off switching circuit that is needed for the motion control of a molecular robot has also been developed.

Free Research Field

制御工学

Academic Significance and Societal Importance of the Research Achievements

生体分子反応系という高次元非線形系に対して、制御理論を適用することの有用性や可能性を示すことができた。本研究を通じて、分子ロボット研究に制御理論研究者が参画する一助になれば幸いである。